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Publikováno v:
European Journal of Clinical Pharmacology
Background and objectives N-acetyltransferase 2 (NAT2) metabolize several drugs including isoniazid. We investigated the effect of genotype, geographical difference, and smoking habit on NAT2 phenotype in Ethiopians. Methods Genotyping for NAT2 191G
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine tra
Publikováno v:
Experimental Brain Research
Current therapy for chemotherapy-induced nausea and vomiting includes the use of both 5-HT3 and NK1 receptor antagonists. Acute emesis has largely been alleviated with the use of 5-HT3 receptor antagonists, while an improvement in preventing delayed
Publikováno v:
European Journal of Clinical Pharmacology
Purpose To assess the impact of hepatic or renal impairment on the pharmacokinetics (PK) of edivoxetine. Methods Two separate multi-center, open-label studies with males and females were conducted. Subjects were categorized according to their hepatic
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783540879114
The evolution of antidepressants over the past four decades has involved the replacement of drugswith a multiplicity of effects (e.g., TCAs) by those with selective actions (i.e., SSRIs). This strategywas employed to reduce the adverse effects of TCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a584a708673e7c89c4d9c651944a406d
https://doi.org/10.1007/7355_2007_016
https://doi.org/10.1007/7355_2007_016
Autor:
John D. Catravas, Laryssa McCloud, Anuran Chatterjee, Gunay Yetik-Anacak, Christiana Dimitropoulou
Publikováno v:
The Vascular Endothelium I ISBN: 9783540329664
Angiotensins and kinins are endogenous peptides with diverse biological actions; as such, they represent current and future targets of therapeutic intervention. The field of angiotensin biology has changed significantly over the last 50 years. Our or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7b2517364740d798ce4ecb045ae0140
https://doi.org/10.1007/3-540-32967-6_8
https://doi.org/10.1007/3-540-32967-6_8
Autor:
G. Wiemer, P. Wohlfart
Publikováno v:
Angiotensin Vol. II ISBN: 9783540406419
Angiotensin-I-converting enzyme (ACE) has turned out to be a central target molecule in the successful treatment of many important cardiovascular diseases. The value of ACE inhibitors as therapeutic options has grown with every year over the past 2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bab04fb5415987a2a8c6073c0b01141b
https://doi.org/10.1007/978-3-642-18497-0_16
https://doi.org/10.1007/978-3-642-18497-0_16
Publikováno v:
Angiotensin Vol. II ISBN: 9783540406419
The results from experimental models and randomized controlled clinical trials have shown that the more intense the blockade of the renin-angiotensin system (RAS) is during angiotensin I-converting enzyme (ACE) inhibition or AT1 receptor blockade, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ab77dce39428c24949d2ab23aa89b6
https://doi.org/10.1007/978-3-642-18497-0_20
https://doi.org/10.1007/978-3-642-18497-0_20
Autor:
Marc G. Caron, Christian Pifl
Publikováno v:
Dopamine in the CNS I ISBN: 9783642627262
More than 30 years ago, accumulation of dopamine by brain tissue was demonstrated after intraventricular injection of [3H]dopamine (Glowinski and Iversen 1966). The highest concentration was found in the striatum, the brain region with the highest in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b018b68d051b623b4c9610af0ee1a0e
https://doi.org/10.1007/978-3-642-56051-4_10
https://doi.org/10.1007/978-3-642-56051-4_10
Publikováno v:
Antithrombotics ISBN: 9783642641909
Platelets circulate in the blood stream in a quiescent state but undergo explosive activation at sites of damage to the blood vessel wall, leading to formation of a haemostatic plug and cessation of bleeding. The quiescent state of the platelet is ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::048f97f225aa59c237684d9a9734bd0b
https://doi.org/10.1007/978-3-642-59942-2_8
https://doi.org/10.1007/978-3-642-59942-2_8