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Publikováno v:
Structure and Bonding ISBN: 9783540669432
For the past 20 years, cytochrome P450 researchers have sought to identify and to characterize the reactive intermediates in reactions of these enzymes. This review focuses on one of those postulated intermediates, the ferric heme peroxo complex, [(p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27aab71819e3493ea7a2e85d2541470e
https://doi.org/10.1007/3-540-46592-8_2
https://doi.org/10.1007/3-540-46592-8_2
Autor:
Dar C. Chow, John G. Forte
Publikováno v:
Molecular and Cellular Mechanisms of H+ Transport ISBN: 9783642793035
The primary gastric H+ pump, the H,K-ATPase, belongs to the family of cation pump enzymes called P-type ATPases, which include the Na,K-ATPase and the Ca-ATPase (Jorgenson & Andersen 1988; Inesi & Kirtley 1992). This family of pump proteins all have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe119bb4079884b763ea809ae7c6ac73
https://doi.org/10.1007/978-3-642-79301-1_4
https://doi.org/10.1007/978-3-642-79301-1_4
Autor:
D. M. Blow
Publikováno v:
Bayer-Symposium ISBN: 9783642879685
This introductory review aims to describe the three-dimensional molecular structure found at the active site of crystalline trypsin and its homologues; to show how small substrate analogues and inhibitors have been found to interact with the active s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8604484dec9c81dc343e86456f2e2ee
https://doi.org/10.1007/978-3-642-87966-1_53
https://doi.org/10.1007/978-3-642-87966-1_53
Publikováno v:
Plant Cell Biotechnology ISBN: 9783642731594
For many years the biotransformation of digitoxin or β-methyldigitoxin to digoxin or β-methyldigoxin (Fig. 1) by cell cultures of Digitalis lanata has been studied (Reinhard 1974). This reaction is of pharmaceutical interest, since cardiac glycosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97069da88683c31ca6c5798128e68659
https://doi.org/10.1007/978-3-642-73157-0_36
https://doi.org/10.1007/978-3-642-73157-0_36
Publikováno v:
Bayer-Symposium ISBN: 9783642879685
At the First International Research Conference on Proteinase Inhibitors we reported our findings on lima bean protease inhibitor (LBI)1 up to that time [1]. We confirmed previous observations [2, 3] that commercial LBI could be separated into four to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7606a91f9c2616918c0dfac721a962a
https://doi.org/10.1007/978-3-642-87966-1_40
https://doi.org/10.1007/978-3-642-87966-1_40
Autor:
L. A. Davidson, K. Takayama
Publikováno v:
Mechanism of Action of Antibacterial Agents ISBN: 9783642464058
Reviews of isonicotinic acid hydrazide (isoniazid, INH ; Structure I) containing speculations on its mode of action have been written by Youatt (1969) and Krishna Murti (1975). This review will describe the important effects of INH on mycobacteria an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bdf70727dfab82315f613f85323ebc2
https://doi.org/10.1007/978-3-642-46403-4_6
https://doi.org/10.1007/978-3-642-46403-4_6
Publikováno v:
Bayer-Symposium ISBN: 9783642879685
The object of this work was to obtain synthetic, reversible trypsin inhibitors. The work is based on a consideration of the length of the positively-charged amino acid side-chain which makes its ester, amide or peptide bond most susceptible to cleava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71976c357a9bfb4605800599a23bb1f3
https://doi.org/10.1007/978-3-642-87966-1_59
https://doi.org/10.1007/978-3-642-87966-1_59
Publikováno v:
Bayer-Symposium ISBN: 9783642879685
Recently Luthy et al [1] investigated the mechanism of the interaction between soybean trypsin inhibitor (STI)1 and trypsin by kinetic methods. These authors found that only at very low reactant concentration the reaction is second order with rate co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8457881d0bed07a7593f0d124fe246e3
https://doi.org/10.1007/978-3-642-87966-1_46
https://doi.org/10.1007/978-3-642-87966-1_46
Autor:
George A. Jacoby, Luigi Gorini
Publikováno v:
Mechanism of Action ISBN: 9783642460531
Streptomycin (Sm), the first nontoxic broad spectrum antibiotic also effective against the tubercle bacillus, was isolated from Streptomyces griseus by Schatz, Bugie, and Waksman in 1944. The structures of Sm and several of its active derivatives are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a6e1bac130a7dd45a5b9ff56bc6e82
https://doi.org/10.1007/978-3-642-46051-7_64
https://doi.org/10.1007/978-3-642-46051-7_64