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Publikováno v:
Cell and Tissue Research
Glial cell line–derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote d
Autor:
Eiichiro Mori, Joachim Luginbühl, Sonia Sabate-Soler, Jens Christian Schwamborn, Silvia Bolognin, Alexander Skupin, Stefano Magni, Kaoru Kinugawa, Kamil Grzyb, Lisa M. Smits, Jay W. Shin
Publikováno v:
Cell and Tissue Research
Human stem cell-derived organoids have great potential for modelling physiological and pathological processes. They recapitulate in vitro the organization and function of a respective organ or part of an organ. Human midbrain organoids (hMOs) have be
Publikováno v:
Pflugers Archiv
Human embryonic stem cell–derived cardiomyocytes develop pronounced hypertrophy in response to angiotensin-2, endothelin-1, and a selected mix of three fatty acids. All three of these responses are accompanied by increases in both basal cytoplasmic
Autor:
David Smith, Frank W. Lewis, Joanna L. Elson, David Tetard, Ilse S. Pienaar, Véronique Hubscher-Bruder, David T. Dexter, Safiya Fairooz, Jérémy Brandel, Meera Soundararajan
Publikováno v:
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02672-y⟩
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02672-y⟩
Ubiquitin proteasome system (UPS) impairment, excessive cellular oxidative stress, and iron dyshomeostasis are key to substantia nigra dopaminergic neuronal degeneration in Parkinson's disease (PD); however, a link between these features remains unco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0753df8db8fd0462fcecf77f14fd15
https://shura.shu.ac.uk/26416/1/204_2020_Article_2672.pdf
https://shura.shu.ac.uk/26416/1/204_2020_Article_2672.pdf
Infection of host cells by mammalian reovirus in culture or in tissues of infected animals results in cell death. Cell death of infected neurons and myocytes contributes to the pathogenesis of reovirus-induced encephalitis and myocarditis in a newbor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::891faae26d86839fa144fcc5fec1be92
https://doi.org/10.1007/82_2020_225
https://doi.org/10.1007/82_2020_225
Publikováno v:
Essentials of Diagnostic Pathology ISBN: 9783662603079
The normal red blood cell count is kept by the balance between erythrocyte production and erythrocyte destruction. The regulation of progenitor cells to the erythroid lineage and their maturation are controlled by growth factors, cytokines and, very
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15ff9657540c02a53b23deefb27d3586
https://doi.org/10.1007/978-3-662-60309-3_2
https://doi.org/10.1007/978-3-662-60309-3_2
The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
Autor:
Erik Renström, Nikolina Papac-Milicevic, Anna M. Blom, Gunilla T. Westermark, Ben C. King, Klaudia Kulak
Publikováno v:
Diabetologia
Aims/hypothesis Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigg
Publikováno v:
Histochemistry and Cell Biology
We gratefully acknowledge financial support from the Wellcome Trust (Grant No. WT089803MA to J.M.L.) and the School of Medicine, University of St Andrews. Neurite growth is central to the formation and differentiation of functional neurons and recent
Autor:
Richard Wade-Martins, Marta Cherubini
Publikováno v:
Cell and Tissue Research
Preferential degeneration of dopamine neurons (DAn) in the midbrain represents the principal hallmark of Parkinson's disease (PD). It has been hypothesized that major contributors to DAn vulnerability lie in their unique cellular physiology and archi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5cc9e60b03bb8f6c54f5ed0bb52906
https://ora.ox.ac.uk/objects/uuid:db6025ad-7d2d-4ae5-bd80-6562441e2cb1
https://ora.ox.ac.uk/objects/uuid:db6025ad-7d2d-4ae5-bd80-6562441e2cb1
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Journal of molecular medicine 93(8), 905-916 (2015). doi:10.1007/s00109-015-1275-1
Journal of molecular medicine 93(8), 905-916 (2015). doi:10.1007/s00109-015-1275-1
Photooxidative damage and chronic innate immune activation have been implicated in retinal pigment epithelium (RPE) dysfunction, a process that underlies blinding diseases such as age-related macular degeneration (AMD). To identify a potential molecu