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Publikováno v:
Leukemias ISBN: 9783642770852
Interleukin-2 (IL-2), originally described as T cell growth factor by Morgan et al. in 1975 [29], is the first of a new kind of immunotherapeutic agents which work against established tumors through the modulation of host immune functions. Cloning of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1329ac1b93f069b4da64241c37f17d0b
https://doi.org/10.1007/978-3-642-77083-8_18
https://doi.org/10.1007/978-3-642-77083-8_18
Publikováno v:
Adjuvant Therapy of Breast Cancer IV ISBN: 9783642847479
Of the many types of drug resistance reported in the literature, one of the best characterized is classic multidrug resistance, a genetically determined type of resistance to chemotherapy [1,2]. Cancers exhibiting intrinsic multidrug resistance media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68182058897baec250a67705400ba2ac
https://doi.org/10.1007/978-3-642-84745-5_7
https://doi.org/10.1007/978-3-642-84745-5_7
Autor:
C. Jasmin
Publikováno v:
Adjuvant Therapy of Breast Cancer IV ISBN: 9783642847479
Stem cell models of malignant tumors have been based on the existence of three categories of cells within the total tumor cell population: (a) proliferating, self-renewing stem cells, (b) proliferating, non-self-renewing (transitional) cells and (c)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caa690b1f1827daac3f264436be29d24
https://doi.org/10.1007/978-3-642-84745-5_2
https://doi.org/10.1007/978-3-642-84745-5_2
Publikováno v:
Cancer Therapy ISBN: 9783642846151
In many pathological states, including tumor growth and a wide variety of non-neoplastic diseases, the disease itself is driven by persistent and often uncontrolled neovascularization (Folkman, 1992). A large number of factors derived from normal and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b8099e9fd874d6d82e48763956e857
https://doi.org/10.1007/978-3-642-84613-7_23
https://doi.org/10.1007/978-3-642-84613-7_23
Publikováno v:
Pathophysiology and Pharmacology of Erythropoietin ISBN: 9783642770760
The Friend virus complex consists of a replication competent virus, the Friend murine leukemia virus (F-MuLV) and a replication defective virus, the Friend spleen focus-forming virus (SFFV). The SFFV defective component is responsible for the inducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e62566bd811e713003d612fb9079e5e
https://doi.org/10.1007/978-3-642-77074-6_3
https://doi.org/10.1007/978-3-642-77074-6_3
Publikováno v:
Lymphohaematopoietic Growth Factors in Cancer Therapy II ISBN: 9783642778032
Lymphocytes from healthy individuals are able to kill certain tumour cells and immature haematopoietic cells in vitro spontaneously. This type of cytotoxicity was described some years ago as “natural cytotoxicity” because it was present spontaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a8067a19e662992937b71a6b581fac6
https://doi.org/10.1007/978-3-642-77801-8_3
https://doi.org/10.1007/978-3-642-77801-8_3
Publikováno v:
Acute Leukemias ISBN: 9783540539490
The development of resistance to chemotherapeutic agents is still a major cause of treatment failure in cancer patients. The mechanisms by which drug resistance develops are poorly understood. Cyclophosphamide (CP) is widely used in the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8506255e5ecb76db212b74917bd32f02
https://doi.org/10.1007/978-3-642-76591-9_11
https://doi.org/10.1007/978-3-642-76591-9_11
Autor:
Ulrich Keilholz, C. Degenhart, Werner Hunstein, Wolfgang Tilgen, B. Brado, M. Richter, A. Wein, E. Seither, Lothar Bergmann, C. Scheibenbogen
Publikováno v:
Cytokines in Hemopoiesis, Oncology, and AIDS II ISBN: 9783540552420
Interleukin-2 (IL-2) has been used since 1984 as a single agent or in combination with lymphokine-activated killer cells [l–4] to treat human malignancies. More recently a combination therapy of interferon-alpha and IL-2 has been administered [5–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::096ffbd97db10ccd5ca0e6e7bbb7b007
https://doi.org/10.1007/978-3-642-48715-6_90
https://doi.org/10.1007/978-3-642-48715-6_90
Publikováno v:
Cytokines in Hemopoiesis, Oncology, and AIDS II ISBN: 9783540552420
Hematopoietic growth factors (GF) have been implicated in regulation and differentiation of hematopoietic precursor cells. One of them, the granulocyte—macrophage colony-stimulating factor (GM-CSF), stimulates production and function of granulocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a6500cbf1336632d66e67277bf859f
https://doi.org/10.1007/978-3-642-48715-6_14
https://doi.org/10.1007/978-3-642-48715-6_14
Autor:
Michael Zühlsdorf, Wolfgang Hiddemann, T. Büchner, C Reuter, Bernhard Wörmann, C. Busemann, Ulrike Auf der Landwehr
Publikováno v:
Cytokines in Hemopoiesis, Oncology, and AIDS II ISBN: 9783540552420
Cytosine arabinoside (ara-C) is one the most effective agents in the treatment of acute myeloid leukemia (ALM) [1]. Its cytotoxicity is believed to result from the formation and incorporation of ara-C triphosphate (ara-CTP) into DNA and an inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e9872891e7457ef4e075619d9fc56b
https://doi.org/10.1007/978-3-642-48715-6_41
https://doi.org/10.1007/978-3-642-48715-6_41