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Autor:
Jason T. Lee, András Füredi, Oliver Langer, R. Michael van Dam, Divya Maheshwari, Theresa Falls, Pavitra Kannan, Gergely Szakács, Severin Mairinger, Sabina Dizdarevic, Jeffrey Collins, Thomas Wanek
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher
Autor:
Céleste Lebbé, Andrew S. Brohl, Meliessa H. Hennessy, Michele Milella, Patrick Terheyden, Kent C. Shih, Paul Nghiem, Isaac Brownell, Gerald P. Linette, Karl D. Lewis, Shailender Bhatia, Murtuza Bharmal, Omid Hamid, Michael Schlichting, Sandra P. D'Angelo, Janice M. Mehnert, Matthias Hunger
Publikováno v:
Cancer Immunology, Immunotherapy
Background Response rates are primary endpoints in many oncology trials; however, correlation with overall survival (OS) is not uniform across cancer types, treatments, or lines of therapy. This study explored the association between objective respon
Autor:
Heather A. Jacene, Richard L. Wahl
Publikováno v:
Therapeutic Nuclear Medicine ISBN: 9783540367185
The rationale for the use of radioimmunotherapy (RIT) in cancer is that radiolabeled monoclonal antibodies specifically target and irradiate tumor cells while sparing normal tissues. The specific tumor targeting theoretically allows higher doses of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a76494aef2ff584990873c939859ff7f
https://doi.org/10.1007/174_2013_943
https://doi.org/10.1007/174_2013_943
Autor:
Jens Hasskarl
Publikováno v:
Recent Results in Cancer Research ISBN: 9783642544897
Sorafenib (BAY 43-9006, Nexavar®) is an oral multiple tyrosine kinase inhibitor. Main targets are receptor tyrosine kinase pathways frequently deregulated in cancer such as the Raf–Ras pathway, vascular endothelial growth factor (VEGF) pathway, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e329b07e450489d052e07eae58e039b
https://doi.org/10.1007/978-3-642-54490-3_8
https://doi.org/10.1007/978-3-642-54490-3_8
Autor:
David S. Schrump
Publikováno v:
Epigenetic Therapy of Cancer ISBN: 9783642384035
Lung cancer cells and cell lines have been extensively studied for epigenetic alterations including global and gene-specific DNA hypermethylation, aberrant histone acetylation and methylation, and resultant gene expression changes. These epigenetic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c4d79a881e56c127a430862a74ea4b5
https://doi.org/10.1007/978-3-642-38404-2_11
https://doi.org/10.1007/978-3-642-38404-2_11
Publikováno v:
Therapeutic Kinase Inhibitors ISBN: 9783642282959
Kinase inhibitors have emerged as effective cancer therapeutics in a variety of human cancers. Glioblastoma (GBM), the most common malignant brain tumor in adults, represents a compelling disease for kinase inhibitor therapy because the majority of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16508bc101ff839b15db7d8d2ec4390d
https://doi.org/10.1007/82_2011_178
https://doi.org/10.1007/82_2011_178
Autor:
Bonny Blackard, Michael J. Thun
Publikováno v:
Cancer Prevention II ISBN: 9783540692966
This paper briefly reviews the pharma-cologic effects of nonsteroidal antiinflammatory drugs (NSAIDs) that influence the risks and benefits of using these drugs prophylactically for cancer. It describes the metabolism of arachidonic acid through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9f66b6613e8bf39e38b660fafac535
https://doi.org/10.1007/978-3-540-69297-3_20
https://doi.org/10.1007/978-3-540-69297-3_20
Autor:
Yuxin Li, Powel H. Brown
Publikováno v:
Cancer Prevention II ISBN: 9783540692966
The successful demonstration that the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene reduce the risk of breast cancer has stimulated great interest in using drugs to prevent breast cancer in high-risk women. In addition, rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f429da08d53b867894cdc45921f449b0
https://doi.org/10.1007/978-3-540-69297-3_13
https://doi.org/10.1007/978-3-540-69297-3_13
Autor:
Steffen Heeger
Publikováno v:
Pancreatic Cancer ISBN: 9783540712664
The epidermal growth factor receptor (EGFR)-mediated pathway is one of the most promising targets for the development of new strategies in anticancer treatments. The so-called "small molecule" tyrosine kinase inhibitor erlotinib has gained marketing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a769d122d38155c7906453290d9b8aae
https://doi.org/10.1007/978-3-540-71279-4_15
https://doi.org/10.1007/978-3-540-71279-4_15
Autor:
Y. Yang, John A. Beutler, Christy A. Sasiela, Barry R. O'Keefe, Jirouta Kitagaki, Allan M. Weissman
Publikováno v:
The Ubiquitin System in Health and Disease ISBN: 9783540851066
The ubiquitin conjugating system represents a rich source of potential molecular targets for cancer and other diseases. One target of great interest is the RING finger ubiquitin ligase (E3) Hdm2/Mdm2, which is frequently overexpressed in cancer and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1b0c13e78b3cdc62724835dd32174c
https://doi.org/10.1007/2789_2008_108
https://doi.org/10.1007/2789_2008_108