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Autor:
G. R. Bernard
Publikováno v:
Update in Intensive Care and Emergency Medicine ISBN: 9783642850387
Since the first report of Northover and Subramanian [1] in 1962 on the use of aspirin to prevent death due to endotoxin shock in mongrel dogs, there has been a near-continuous stream of investigations the results of which support the potential for cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d86c18952d6f4e43987326b36a32b9d
https://doi.org/10.1007/978-3-642-85036-3_37
https://doi.org/10.1007/978-3-642-85036-3_37
Autor:
Karl Heinz Rahn, Gerd Bönner
Publikováno v:
Prostacyclin and Hypertension ISBN: 9783540521402
The structural elucidation of prostacyclin (PGI2) showed that this substance is to be regarded as a typical cyclooxygenase product of the eicosanoids. The chemical structure of prostacyclin (Fig. 2) is described as 9-deoxo-6,9α-epoxy-delta5-PGF1α [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54cdae07d3d2a9d13d4774879bd98894
https://doi.org/10.1007/978-3-642-95608-9_2
https://doi.org/10.1007/978-3-642-95608-9_2
Autor:
P. J. Lefebvre, A. S. Luyckx
Publikováno v:
Glucagon II ISBN: 9783642690211
Prostaglandins (PGs) are a group of compounds which have been found to exert numerous and potent physiologic and pharmacologic effects. Their existence was originally reported in seminal fluid about 50 years ago (Kurzrok and Lieb 1930; Goldblatt 1933
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43d64fc83c3e3fc3de0ce0e703666d5c
https://doi.org/10.1007/978-3-642-69019-8_6
https://doi.org/10.1007/978-3-642-69019-8_6
Autor:
O. Oelz
Publikováno v:
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics ISBN: 9783642685484
Knowledge of the oxidative transformation of arachidonic acid into several distinct derivatives has increased considerably in recent years. The products consist of prostaglandins, prostacyclin (PGI2), thromboxanes, and leukotrienes (Samuelsson 1981).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7fd6ce839fd896f3a16c4e3ef5ca561
https://doi.org/10.1007/978-3-642-68546-0_4
https://doi.org/10.1007/978-3-642-68546-0_4
Publikováno v:
Recent Developments in Lipid and Lipoprotein Research ISBN: 9783540191469
Interactions between platelets and vascular endothelial cells play a key role in hemostasis and particularly primary hemostasis. In this context, the metabolism of arachidonic acid is believed to be an important point. When platelets are triggered wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e3e695d1d659f6c152ad25dd35c86e
https://doi.org/10.1007/978-3-642-83447-9_16
https://doi.org/10.1007/978-3-642-83447-9_16
Autor:
R. Paoletti
Publikováno v:
Prostaglandin E1 in Atherosclerosis ISBN: 9783540172406
Prostaglandin E1 (PGE1) was discovered by Bergstrom’s group in the 1960s and the structure was originally defined (Fig. 1). PGE1 is a component of the prostaglandin (PG) group and is called a stable prostaglandin; it can be much more active in tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3437fc0f407e4713b9ffcc796a943e63
https://doi.org/10.1007/978-3-642-71679-9_1
https://doi.org/10.1007/978-3-642-71679-9_1
Publikováno v:
Radioimmunoassay in Basic and Clinical Pharmacology ISBN: 9783642718113
Arachidonic acid is the precursor of a number of important mediators in the regulation of the microenvironment. It is released by the action of phospholipases on membrane phospholipids and then modified by enzymes of the cyclooxyge- nase pathway to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dece0354a81895a8302afde976896ace
https://doi.org/10.1007/978-3-642-71809-0_19
https://doi.org/10.1007/978-3-642-71809-0_19