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Autor:
Federica Andreoni, Katrin Schilcher, Annelies S. Zinkernagel, Jerzy Madon, Partho Ghosh, Claudia Zürcher, Ulrich Matt, Satoshi Uchiyama, Victor Nizet, Miriam Ender, Reto A. Schuepbach
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
JOURNAL OF MOLECULAR MEDICINE-JMM
JOURNAL OF MOLECULAR MEDICINE-JMM
Group A Streptococcus (GAS) is a human pathogen causing a wide range of mild to severe and life-threatening diseases. The GAS M1 protein is a major virulence factor promoting GAS invasiveness and resistance to host innate immune clearance. M1 display
Autor:
Nicolaus Kröger, Thomas Stübig
Publikováno v:
Cancer Immunology ISBN: 9783662464090
Acute lymphoblastic leukaemia (ALL) rises from lymphoid progenitors. ALL cells show vast antigens linked to normal B-cell development and may be used as targets for immunotherapy. Since CD20 is expressed in B-ALL cells, rituximab, an anti-CD20 antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a63216442c537f9e88a026b960f0d20
https://doi.org/10.1007/978-3-662-46410-6_6
https://doi.org/10.1007/978-3-662-46410-6_6
Publikováno v:
Vaccine Analysis: Strategies, Principles, and Control ISBN: 9783662450239
Historically, vaccines have predominantly been manufactured through complex biological processes (growth in embryonic chicken eggs, bacterial fermentation, and mammalian cell culture) that can be challenging to control and reproduce. Although the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6adc156a48b2d3fd9354fd8426f598bc
https://doi.org/10.1007/978-3-662-45024-6_13
https://doi.org/10.1007/978-3-662-45024-6_13
Autor:
Heather A. Jacene, Richard L. Wahl
Publikováno v:
Therapeutic Nuclear Medicine ISBN: 9783540367185
The rationale for the use of radioimmunotherapy (RIT) in cancer is that radiolabeled monoclonal antibodies specifically target and irradiate tumor cells while sparing normal tissues. The specific tumor targeting theoretically allows higher doses of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a76494aef2ff584990873c939859ff7f
https://doi.org/10.1007/174_2013_943
https://doi.org/10.1007/174_2013_943
Autor:
Sebastian Eigner, Katerina Eigner Henke, Frantisek Melichar, René Leyva Montaña, Milos Beran, Denis R. Beckford Vera
Publikováno v:
Recent Results in Cancer Research ISBN: 9783642279935
The epidermal growth factor receptor (EGFR) is a rational target of anticancer therapies due to its overexpression in a variety of malignant epithelial tumors. Nevertheless, this antigen is also present in normal tissues. Consequently, monoclonal ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f60879eccc3d801627b44b0cfab5b83b
https://doi.org/10.1007/978-3-642-27994-2_16
https://doi.org/10.1007/978-3-642-27994-2_16
Autor:
Lonberg N
Publikováno v:
Therapeutic Antibodies ISBN: 9783540732587
Since the 1986 regulatory approval of muromonomab-CD3, a mouse monoclonal antibody (MAb) directed against the T cell CD3epsilon antigen, MAbs have become an increasingly important class of therapeutic compounds in a variety of disease areas ranging f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6fef6242a2dc0e0197dcf6be7eb4af
https://doi.org/10.1007/978-3-540-73259-4_4
https://doi.org/10.1007/978-3-540-73259-4_4
Autor:
S. Jahn, K. Schmitt-Rau
Publikováno v:
Biologics in General Medicine ISBN: 9783540290179
Efalizumab is a humanized monoclonal antibody binding to the lymphocyte function-associated antigen (LFA-1). LFA-1 belongs to the family of β2 integrins and is expressed on the surface of T cells (CD4+ cells, Thelper cells; CD8+ cells, cytotoxic T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6db43fa2ea2956f9558656297a66b8ed
https://doi.org/10.1007/978-3-540-29018-6_5
https://doi.org/10.1007/978-3-540-29018-6_5
Autor:
J. Y. Blay, G. T. Stevenson, Noel-Jean Milpied, Veronique Leblond, N. Blanc-Brunat, Jean Louis Touraine, Jeanne L. Garnier
Publikováno v:
Immunosurveillance, Immunodeficiencies and Lymphoproliferations ISBN: 9783642626760
The treatment of post-transplant lymphomas still needs major improvements in order to put the patient in remission and to retain graft function. Chemotherapy is far too toxic in these patients. A more specific treatment such as anti-B-cell monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::187ec4cb2a7916dc442b312090cd254e
https://doi.org/10.1007/978-3-642-56352-2_14
https://doi.org/10.1007/978-3-642-56352-2_14
Autor:
J. M. McNally, Raymond M. Welsh
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642627248
Acquired immunity against viruses relies on the activation of virus-specific T cells to combat and clear the virus from the infected host. CD8 T cells are essential to this process, due to their ability to differentiate between self and non-self anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d2669fa18da6a2cea42420768b59d24
https://doi.org/10.1007/978-3-642-56055-2_3
https://doi.org/10.1007/978-3-642-56055-2_3
Autor:
B. Bielekova, R. Martin
Publikováno v:
New Concepts in Pathology and Treatment of Autoimmune Disorders ISBN: 9783662044520
Multiple sclerosis (MS) is a chronic inflammatory/demyelinating disease of the central nervous system (CNS) with various degrees of axonal loss [1, 2] in which autoreactive CD4+ T cells are considered to play a crucial role [3–5]. In different form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df8a5c88a305936d7ea7621dea46350a
https://doi.org/10.1007/978-3-662-04450-6_5
https://doi.org/10.1007/978-3-662-04450-6_5