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Publikováno v:
Biochemical Sites of Insecticide Action and Resistance ISBN: 9783540676256
The world market for insecticides is still dominated, albeit declining, by compounds that irreversibly inhibit acetylcholinesterase (AChE), one of the most essential enzymes in the central nervous system of insects, responsible for the cleavage of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39410a8f14a77042386ce07ea7013251
https://doi.org/10.1007/978-3-642-59549-3_4
https://doi.org/10.1007/978-3-642-59549-3_4
Autor:
A. Nordberg
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
I. In Vitro Receptor Binding Studies The discovery of the existence of nicotinic acetylcholine receptors (nAChRs) in the brain and their involvement in CNS higher functions such as learning and memory are relatively new phenomena. The nAChRs in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2bccf53421dcb5dd0ae4c3d3b1dd708
https://doi.org/10.1007/978-3-642-57079-7_21
https://doi.org/10.1007/978-3-642-57079-7_21
Autor:
M. Zoli
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
A cholinergic neuron, i.e., a neuron which utilizes acetylcholine (ACh) as a neurotransmitter, has several specific neurochemical features: a releasable pool of ACh; the enzyme necessary for ACh synthesis, i.e., choline acetyl-transferase (ChAT); the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a3faf48dda9f2781c9170d11b333e7
https://doi.org/10.1007/978-3-642-57079-7_2
https://doi.org/10.1007/978-3-642-57079-7_2
Autor:
M. Zoli
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
Nicotinic transmission in neurons is likely to differ substantially from that at the neuromuscular synapse (see below; ROLE and BERG 1996; WALMSLEY et al. 1998; ZOLI and AGNATI 1996), and neurons and muscle cells themselves differ in some essential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be8b5a948f1e5a8890d4dacbb6cd6f0
https://doi.org/10.1007/978-3-642-57079-7_9
https://doi.org/10.1007/978-3-642-57079-7_9
Autor:
J.-P. Changeux, L. M. Marubio
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle, the central nervous system (CNS), and the peripheral nervous system (PNS). Nicotine, a specific agonist of these receptors, exerts diverse cellular and behavioural effects. Aside fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656e2e04634451482630f65ee0f1ad9b
https://doi.org/10.1007/978-3-642-57079-7_20
https://doi.org/10.1007/978-3-642-57079-7_20
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
In their efforts to throw light on the complex phenomena occurring in living cells, scientists are always looking for simplified experimental systems with controlled parameters and a limited number of variables; however, one of the factors limiting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a0672abdb2f8c2cbe4edc8be3754b9
https://doi.org/10.1007/978-3-642-57079-7_14
https://doi.org/10.1007/978-3-642-57079-7_14
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
Nicotinic acetylcholine receptors (nAChRs) are pentameric integral membrane proteins made up from 1-4 different subunits. Traditionally classified into “muscle type” and “neuronal type”, it is now clear that only the expression of muscle nACh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c244363db0ec61905f03e76e64621f15
https://doi.org/10.1007/978-3-642-57079-7_18
https://doi.org/10.1007/978-3-642-57079-7_18
Autor:
J. M. Mcintosh
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
Toxins have historically played a central role in defining both the structure and function of nicotinic acetylcholine receptors (nAChRs). Toxin sensitivity serves as a valuable way to distinguish among nAChR subtypes, particularly when the subunit co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca48f26d52b96544e3a5771dabf08926
https://doi.org/10.1007/978-3-642-57079-7_17
https://doi.org/10.1007/978-3-642-57079-7_17
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
Although the psychopharmacological effects of nicotine have been known since the last century, it was not until the end of the 1980s that neuronal nicotinic acetylcholine receptors (nAChRs) were found to be functional in the central nervous system (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78ef12e3982fed20df39355f9a6f55a3
https://doi.org/10.1007/978-3-642-57079-7_13
https://doi.org/10.1007/978-3-642-57079-7_13
Autor:
Michael M. Francis, Roger L. Papke
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
In the last ten years the field of neuroscience has made tremendous progress toward understanding some of the fundamental aspects of brain function. Patch clamp methods and brain slice recordings, along with new information about the molecular biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb17caeb0fea148f75aa74a87eabe12c
https://doi.org/10.1007/978-3-642-57079-7_12
https://doi.org/10.1007/978-3-642-57079-7_12