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Autor:
Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder
Publikováno v:
European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Purpose Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic mo
Autor:
Byung Won Yoo, Byung Hak Jin, J. M. Park, Min Soo Park, Jun Yeon Lee, Jae Soo Shin, Jung Hye Kim
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety
Autor:
Felix Lötsch, Klaus Kaczirek, Fredrik Waneck, Herbert Auer, Judith Naderer, Mirjam Groger, Tomislava Skuhala, Michael Ramharter
Publikováno v:
Parasitology Research
Cystic echinococcosis (CE) is a widespread zoonosis caused by the species complex Echinococcus granulosus. Albendazole (ABZ)—the first-line anthelminthic drug for medical treatment of CE—is metabolized in vivo to the active derivative ABZ-sulphox
Autor:
Gerd A. Kullak-Ublick, Christoph Gubler, Katharina Spanaus, Alexander Jetter, Manfred G. Ismair, Tatiana Claro da Silva
Publikováno v:
European Journal of Clinical Pharmacology
Eur J Clin Pharmacol
Eur J Clin Pharmacol
Purpose In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Additionally, mRNA content and protein expression of the transporter OAT
Autor:
Jonas Jensen, Steen Jakobsen, Jørgen Frøkiær, L.H. Pedersen, Lise Wogensen, Niels Jessen, Ole Lajord Munk
Publikováno v:
EJNMMI Research
Pedersen, L H, Jensen, J B, Wogensen, L, Munk, O L, Jessen, N, Frøkiær, J & Jakobsen, S 2016, ' Renal PET-imaging with 11C-metformin in a transgenic mouse model for chronic kidney disease ', EJNMMI Research, vol. 6, 54 . https://doi.org/10.1186/s13550-016-0211-x
Pedersen, L H, Jensen, J B, Wogensen, L, Munk, O L, Jessen, N, Frøkiær, J & Jakobsen, S 2016, ' Renal PET-imaging with 11C-metformin in a transgenic mouse model for chronic kidney disease ', EJNMMI Research, vol. 6, 54 . https://doi.org/10.1186/s13550-016-0211-x
Organic cation transporters (OCTs) in the renal proximal tubule are important for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) alter the expression of OCT. Metformin is a well-known substrate for OCT, and rece