Zobrazeno 1 - 10
of 14
pro vyhledávání: ''
Autor:
Walter Fiedler, Stefan Schwartz, Jochim Reinert, Klaus Wethmar, Matthias Stelljes, Antonia Beitzen-Heineke
Publikováno v:
Annals of Hematology
Treatment options for relapsed or refractory B-lymphoblastic leukaemia (r/r B-ALL) are limited and the prognosis of these patients remains dismal, but novel immunotherapeutic options such as the anti-CD22 antibody–drug-conjugate Inotuzumab-Ozogamic
Autor:
Nicolette C. Bishop, Alexandra L. Shill, Amber N. Leonard, Alice E. Thackray, David J. Stensel
Publikováno v:
European Journal of Applied Physiology
Purpose Asprosin, an orexigenic hormone that stimulates hepatic glucose release, is elevated in insulin resistance and associated with obesity. Plasma asprosin concentrations may also be related to female sex hormone levels; higher levels are reporte
Six weeks of dynamic apnoeic training stimulates erythropoiesis but does not increase splenic volume
Publikováno v:
European Journal of Applied Physiology
Purpose This study examined the influence of dynamic apnoea training on splenic volume and haematological responses in non-breath-hold divers (BHD). Methods Eight non-BHD performed ten maximal dynamic apnoeas, four times a week for six weeks. Splenic
Autor:
Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder
Publikováno v:
European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Purpose Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic mo
Autor:
Ben Kirk, Dominic A. Doran, James P. Morton, Simon C. Fleming, Andy Sparks, Robert Fearn, Jamie N. Pugh, Graeme L. Close, Carl Langan-Evans
Publikováno v:
European Journal of Applied Physiology
Purpose To evaluate the effects of probiotic supplementation on gastrointestinal (GI) symptoms, circulatory markers of GI permeability, damage, and markers of immune response during a marathon race. Methods Twenty-four recreational runners were rando
Autor:
Céleste Lebbé, Andrew S. Brohl, Meliessa H. Hennessy, Michele Milella, Patrick Terheyden, Kent C. Shih, Paul Nghiem, Isaac Brownell, Gerald P. Linette, Karl D. Lewis, Shailender Bhatia, Murtuza Bharmal, Omid Hamid, Michael Schlichting, Sandra P. D'Angelo, Janice M. Mehnert, Matthias Hunger
Publikováno v:
Cancer Immunology, Immunotherapy
Background Response rates are primary endpoints in many oncology trials; however, correlation with overall survival (OS) is not uniform across cancer types, treatments, or lines of therapy. This study explored the association between objective respon
Autor:
Ralf Gold, Aiden Haghikia, Maren Peschke, Gisa Ellrichmann, Kerstin Hellwig, De-Hyung Lee, Jan Bolz, Alexander Duscha, Ralf A. Linker
Publikováno v:
Journal of Neurology
Background With ocrelizumab another drug is available for the treatment of multiple sclerosis (MS). Little is known on the long-term use of ocrelizumab on immune cell subsets, and no surrogate markers are available. Rituximab (RTX) has been in off-la
Autor:
Byung Won Yoo, Byung Hak Jin, J. M. Park, Min Soo Park, Jun Yeon Lee, Jae Soo Shin, Jung Hye Kim
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology
Purpose The current treatment approaches for Coats’ disease by intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents (ranibizumab or conbercept) combined with laser therapy were evaluated for the efficacy during the treatm
Autor:
Klaus Schmierer, Francesca Ammoscato, Helen Lock, David Baker, Zhifeng Mao, Bryan Ceronie, Hilary Longhurst, Benjamin Meir Jacobs, Nicolas Dubuisson, Gavin Giovannoni
Publikováno v:
Journal of Neurology
Background The mechanism of action of oral cladribine, recently licensed for relapsing multiple sclerosis, is unknown. Objective To determine whether cladribine depletes memory B cells consistent with our recent hypothesis that effective, disease-mod