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Publikováno v:
Oncology Reports.
Breast cancer is the leading cause of cancer‑-associated deaths in women. Combination immunotherapy attracts great interest as a treatment for breast cancer. However, there are no studies on the use of cytotoxic T‑lymphocyte antigen 4 (CTLA‑4)
Autor:
Hideyuki Ohzawa, Yoshinori Hosoya, Akira Saito, Yuki Kimura, Yuko Kumagai, Joji Kitayama, Hironori Yamaguchi, Alan Kawarai Lefor, Naohiro Sata
Publikováno v:
Oncology Reports
The peritoneal surface is the most frequent site of metastasis disease in patients with gastric cancer. Even after curative surgery and adjuvant chemotherapy, peritoneal recurrences often develop. Exosomes play pivotal roles in tumor metastasis via t
Autor:
Chang Xu, Chen Liu, Bin Yi, Miao Han, Jing‑Yu Li, Xiaoqing Jiang, Hao Qin, Bin Li, Dadong Zhang, Fugen Li, Zhizhen Li, Qingbao Cheng, Yong Yu, Lei Xiong, Zhiquan Qiu, Feiling Feng
Publikováno v:
Oncology Reports
Targeted therapy based on specific genetic alterations has been proven to be an effective treatment for various types of cancer. In the present study, we aimed to explore the efficacy of personalized targeted therapy guided by targeted deep sequencin
Publikováno v:
Oncology Reports.
Establishing a prognostic genetic signature closely related to the tumor immune microenvironment (TIME) to predict clinical outcomes is necessary. Using the Gene Expression Omnibus (GEO) database of a non‑small cell lung cancer (NSCLC) cohort and t
Autor:
Dongmin Chang, Jia Ma, Xin Zhang, Qingnuo Zeng, Bin Hou, Jianhui Li, Zhao Liu, Wenhan Li, Peng Xia
Publikováno v:
Oncology Reports
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the fourth leading cause of cancer‑related mortality worldwide. Thus, identification of the mechanisms involved in the progression of CRC has become a crucial element of facili
Autor:
Stefano Cascinu, Federica Bertolini, Cinzia Baldessari, Letizia Scurani, Luca Fabbiani, Giorgia Guaitoli, Laura Botticelli, Lorena Losi, Fausto Barbieri, Federico Banchelli, Andrea Ambrosini-Spaltro, Antonino Maiorana
Publikováno v:
International Journal of Oncology.
The tumor immune microenvironment (TME) and immune checkpoints have been reported to serve a role in the pathogenesis of malignant mesothelioma (MM) and treatment outcome. Additionally, mismatch Repair (MMR) deficiency appears to enhance the response
Autor:
Pawel Miotla, Katarzyna Pogoda, Jacek Tabarkiewicz, Izabela Winkler, Marek Gogacz, Aneta Adamiak, Maria Pyszniak, Dorota Darmochwal-Kolarz, Tomasz Rechberger, Andrzej Semczuk
Publikováno v:
Oncology Reports. 37:3107-3115
The present study was carried out to assess the percentage of T helper 17 (Th17) lymphocytes in blood and tissue and IL-17A serum concentrations in patients with epithelial ovarian tumors. Two isoforms, IL-17A and IL-17F, as well as IL-21 and IL-22,
Autor:
Haruyoshi Tanaka, Chie Tanaka, Mitsuro Kanda, Suguru Yamada, Goro Nakayama, Hiroyuki Sugimoto, Masamichi Hayashi, Dai Shimizu, Masahiko Koike, Tsutomu Fujii, Daisuke Kobayashi, Naoki Iwata, Yasuhiro Kodera, Michitaka Fujiwara, Masahiro Shibata, Hideki Takami
Publikováno v:
International Journal of Oncology
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal. Novel molecular targets for diagnosis and therapy is urgently required. This study evaluated expression and functions of the protein arginine methyltransferase 5 (PRMT5) in HCC. Usin
Autor:
Xiaomei Zhang, Yibin Jia, Cong Wang, Bin Yao, Nana Wang, Bingxu Tan, Qingxu Song, Zhu-Long Liu, Yufeng Cheng, Jianbo Wang
Publikováno v:
Molecular Medicine Reports
Abnormal paired box 9 (PAX9) expression is associated with tumorigenesis, cancer development, invasion and metastasis. The present study investigated the prognostic significance of PAX9 in esophageal squamous cell carcinoma (ESCC) and its role in pre
Autor:
Takayuki Asao, Takeo Takahashi, Kyoji Ogoshi, Masahiko Motegi, Yosuke Takakusagi, Hiroyuki Kuwano, Hisanori Shoji
Publikováno v:
Oncology Reports
The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present