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Publikováno v:
Oncology Letters.
Osteosarcoma (OS) occurs in both children and adolescents and leads to a poor prognosis. 2-methoxyestradiol (2-ME) has a strong antitumor effect and is effective against numerous types of tumor. However, 2-ME has a low level of antitumor effects in O
Autor:
Xiao-Bo Tong, Xiaotao Gao, Kazuko Kita, Atsushi Suzuki, Jingyao Yu, Xiaosong Liu, Kuihua Li, Nobuo Suzuki, Fuhong Gao
Publikováno v:
Biomedical Reports
Lifeceramics (LC) is made of zeolite and oyster shell and is hypothesized to act as an anti-oxidative agent. In the present study, the effects of LC-treated water (LC water) on the concentration of serum uric acid (SUA) and the hemorheological parame
Publikováno v:
Experimental and Therapeutic Medicine
Thyroid dysfunction has been previously reported during treatment with certain small-molecule multi-tyrosine kinase inhibitors, including sunitinib and sorafenib. Apatinib, which has a similar mechanism of action to these inhibitors, has reportedly i
Autor:
Atsushi Suetsugu, Nobuhiko Nakamura, Takao Miwa, Kenji Imai, Koji Takai, Makoto Shiraki, Yoshikazu Ikoma, Junichi Kitagawa, Hiroyasu Sakai, Masahito Shimizu, Yohei Shirakami, Tatsunori Hanai, Nobuhiro Kanemura
Publikováno v:
Molecular and Clinical Oncology
Recently, treatments for chronic hepatitis C virus (HCV) infection have significantly improved by the development of direct-acting antiviral agents (DAAs) and almost all patients with HCV can complete antiviral treatment without apparent adverse even
Autor:
Ovidiu Mușat, Marius Cristian Șuță, Nicolae Constantin Balica, Simona Stanca, Diana‑Maria Dărăbuş, Iasmina Yasar, Cosmin Roșca, Olimpiu Karancsi
Publikováno v:
Experimental and Therapeutic Medicine
Due to their anti-inflammatory, antiangiogenic and antiedematous properties, corticosteroids have been commonly used in the treatment of retinal diseases. Intravitreal administration of steroids offers the maximal drug efficacy and the lowest risk of
Publikováno v:
Experimental and Therapeutic Medicine.
Hyperglycemia-induced oxidative stress and inflammation are hallmarks of liver damage in diabetes mellitus. Accumulating evidence has demonstrated that Pluchea indica leaf ethanol extract (PILE) possesses strong antioxidant and anti-inflammatory prop
Autor:
Yasuyoshi Miyata, Hideki Sakai, Asato Otsubo, Tomohiro Matsuo, Yuichiro Nakamura, Tsutomu Yuno, Yuta Mukae, Kensuke Mitsunari, Kyohei Araki, Kojiro Ohba
Publikováno v:
Oncology Letters
c-Met is a receptor tyrosine kinase that binds a specific ligand, namely hepatocyte growth factor (HGF). The HGF/c-Met system is important for malignant aggressiveness in various types of cancer, including bladder cancer (BC). However, although phosp
Autor:
Ovidiu Gabriel Bratu, Camelia Cristina Diaconu, Ana Maria Alexandra Stănescu, Ovidiu Fratila, Dan Liviu Dorel Mischianu, Arsenie Dan Spinu, Simona Bungau, Roxana Bohiltea
Publikováno v:
Exp Ther Med
Botulinum toxin is a substance produced by Clostridium Botulinum and is responsible for human botulism. This substance is a poison, a neurotoxin, but used in limited quantities it can be a cure for some diseases. It is well connected to a large varie
Autor:
Noelia Puente‑Moncada, Maria Turos‑Cabal, Carmen Rodríguez, Cristina Duarte‑Olivenza, Ana M. Sánchez‑Sánchez, Federico Herrera, Jezabel Rodriguez‑Blanco, Isaac Antolín, Vanesa Martín
Publikováno v:
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
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RUO. Repositorio Institucional de la Universidad de Oviedo
instname
The FMS‑like tyrosine kinase 3 internal tandem duplication (FLT3‑ITD) mutation represents the most frequent genetic alteration in acute myeloid leukemia (AML) and is associated with poor prognosis. The mutation promotes cancer cell survival and p
Autor:
Yuichi Ohnishi, Hirohito Kubo, Hiroyuki Hamada, Tsukasa Sakamoto, Li Zhengguang, Hiroki Yasui, Masahiro Nakajima
Publikováno v:
Oncol Lett
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. OSCC cells are highly invasive, a characteristic that involves epithelial-mesenchymal transition (EMT); the conversion of immotile epithelial cells into motile mesenchymal ce