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Autor:
Tuo Hu, Nan Lan, Xiao jian Wu, Ping Lan, Xiaobin Zheng, Ze‑Rong Cai, Ze‑Xian Chen, Xuan hui Liu, Y. Chen, Xianrui Wu, Chi Zhou
Publikováno v:
Oncology Letters
Patients with inflammatory bowel disease (IBD) are at a higher risk of developing colitis-associated colorectal cancer. The aim of the present study was to investigate the role of CD73 in IBD-associated tumorigenesis. A mouse model of colitis-associa
Publikováno v:
International Journal of Molecular Medicine
Simvastatin is effective in the treatment of osteoporosis, partly through the inhibition of the adipogenesis of bone-marrow derived mesenchymal stem cells (BMSCs). The present study focused on the mechanisms responsible for the inhibitory effects of
Publikováno v:
Experimental and Therapeutic Medicine
Papulopustular rosacea (PPR) is characterized by central facial erythema and transient papules and/or pustules, with or without telangiectases. The treatment of PPR is challenging due to the unclear and complex pathogenesis. In the present retrospect
Autor:
Huali Xu, Guangzhu Lin, Xiaofeng Yu, Hongyan Cao, Guoliang Xu, Dayun Sui, Jianan Geng, Wenwen Fu
Publikováno v:
Experimental and Therapeutic Medicine
The development of abnormal lipid-induced atherosclerosis is initiated with endothelial cell apoptosis. Vascular endothelial cells possess highly developed endoplasmic reticulum (ER), which is involved in lipid metabolism, indicating that ER stress m
Publikováno v:
Experimental and Therapeutic Medicine. 22
Multidrug-resistant (MDR) patterns due to extended-spectrum β-lactamase (ESBL) production in pathogenic bacteria are now becoming prevalent in hospitals worldwide, posing a public health challenge. The aim of the present study was to determine the a
Publikováno v:
Experimental and Therapeutic Medicine
Heparin is a commonly used in the clinic, however, Heparin's effect on endothelial injury remains unclear. The aim of the present study was to evaluate the effects and possible mechanisms of action underlying heparin treatment in lipopolysaccharide (
Publikováno v:
Experimental and Therapeutic Medicine
Increasing evidence suggest that NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis may be the underlying pathological mechanism of sepsis-induced cardiomyopathy. DDX3X, an ATP-dependent RNA helicase, plays a vital role in the forma
Publikováno v:
International Journal of Molecular Medicine
Resveratrol (RSV) and metformin (MET) play a role in the treatment of diabetes; however, the mechanisms through which they mediate insulin resistance by regulating long non-coding RNAs (lncRNAs) remain unknown. The present study was conducted to dete
Publikováno v:
Exp Ther Med
Chemoresistance is the primary cause of the poor outcome of glioblastoma multiforme (GBM) therapy. Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6) is involved in the growth and proliferation of several types of cancer, including ga
Publikováno v:
International Journal of Molecular Medicine
Sphingosine-1-phosphate (S1P) serves an important role in various physiological and pathophysiological processes, including the regulation of cell apoptosis, proliferation and survival. Sphingosine kinase 1 (SPHK1) is a lipid kinase that phosphorylat