Zobrazeno 71 - 80
of 336
pro vyhledávání: ''
Publikováno v:
Molecular Medicine Reports.
Inflammation has been implicated in the pathogenesis of type 2 diabetes (T2D), which is a progressive disease characterized by pancreatic β‑cell dysfunction and apoptosis with consequential insufficient insulin secretion. Autophagy is necessary to
Publikováno v:
Molecular Medicine Reports
Prenatal nicotine exposure (PNE) is closely related to depression in offspring. However, the underlying mechanism is still unclear. We hypothesized that neurosteroid in the hippocampus may mediate PNE‑induced depression‑like behaviors. Nicotine w
Publikováno v:
Molecular Medicine Reports
The present study aimed to assess the protective effects of tetramethylpyrazine (TMP) on the livers of mice fed a high fat diet. The mice were divided into five groups: Regular diet; high fat diet; simvastatin-treated; and low and high dose TMP-treat
Publikováno v:
Molecular Medicine Reports.
Previous studies have demonstrated that ovariectomy may lead to a reduction in antioxidative biomarkers in the myocardium, thus suggesting that estrogens may serve a protective role in the suppression of oxidative stress. Lycium barbarum polysacchari
Autor:
Mengyao Bai, Xiao Wang, Li Shao, Ruyuan Deng, Wan Xu, Xueying Ji, Yun Liu, Yuqing Zhang, Feiye Zhou, Libin Zhou
Publikováno v:
Experimental and Therapeutic Medicine
Butyrate is a major short-chain fatty acid (SCFA) produced by microbial fermentation of dietary fiber in the gastrointestinal tract. Butyrate is also a well-known broad-spectrum histone deacetylase (HDAC) inhibitor. Butyrate has been reported to impr
Publikováno v:
Molecular Medicine Reports.
The gut‑liver axis connects the liver with the intestine via bile acid metabolism. Bile acid dysregulation leads to intestinal dysbiosis, that allows enterogenous pathogenic bacteria, including Gram‑negative bacteria and their products lipopolysa
Publikováno v:
Molecular Medicine Reports
The present study aimed to investigate the antifibrogenic effects of genistein (GEN) on the kidney in streptozotocin (STZ)‑induced diabetic rats and to determine the associated mechanisms. Rats were randomized into four groups: Normal control (N),
Autor:
Wei Zhou, Yixian Jing, Xiaolan Yang, Xiaolei Hu, Mingyue Zou, Fei Liao, Jinpeng Lu, Xin Wang, Bangtian Xu, Tingting Tong, Lei Xi
Publikováno v:
Oncology Reports.
The roles of glutathione S‑transferase pi 1 (GSTP1), glutathione S‑transferase mu 2 (GSTM2) and glutathione S‑transferase alpha 1 (GSTA1) in cisplatin (DDP)‑resistance of solid cancer cells (A549/DDP, SKOV3/DDP and SGC7901/DDP) were compared
Publikováno v:
Molecular Medicine Reports.
The NOD‑like receptor family pyrin domain containing 3 (NLRP3) inflammasome has been reported to contribute to palmitic acid (PA)‑induced lipotoxicity. Nobiletin (Nob) is a polymethoxylated flavonoid derived from citrus fruits that has been repor
Autor:
Liping Zhai, Xu Wang
Publikováno v:
Molecular Medicine Reports
Syringaresinol-di-O-β-D-glucoside (SOG) is a phenolic compound extracted from Polygonatum sibiricum. The present study aimed to investigate the antidiabetic effect of SOG on streptozocin (STZ)-induced diabetic mice and determine the potential underl