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Publikováno v:
International Journal of Oncology
Liver cancer is a leading cause of cancer-related mortality globally. Since hepatitis virus infections have been strongly associated with the incidence of liver cancer, studies concerning the effects of antiviral drugs on liver cancer have attracted
Publikováno v:
Molecular Medicine Reports
Perioperative neurocognitive dysfunction (PND) is a prevalent neurological complication after anesthesia and surgery. Ginkgolide B (GB) has been suggested to improve lipopolysaccharide‑induced learning and memory impairment. The present study aimed
Autor:
Marcela Cristina Robaina, Gabriela Nestal de Moraes, Gustavo Henrique C. Guimarães, Paulo R. R. Costa, Luciana Mayumi Gutiyama, Luize Otero de Carvalho, Bruna dos Santos Mendonça, Barbara Da Costa Reis Monte‑Mor, Raquel Ciuvalschi Maia, Chaquip D. Netto, Luciano Mazzoccoli, Thaís Hancio, Fernanda Costas Casal de Faria
Publikováno v:
International Journal of Oncology. 58
Acute myeloid leukemia (AML) is a complex hematological disorder characterized by blockage of differentiation and high proliferation rates of myeloid progenitors. Anthracycline and cytarabine‑based therapy has remained the standard treatment for AM
Autor:
Yanying Zhong, Fang Xu, Fuyin Le, Qi Zuo, Xingwu Wu, Jiao Cheng, Xiali Zhang, Buzhen Tan, Chen Luo
Publikováno v:
Oncology Reports
Advanced and recurrent ovarian cancer has a poor prognosis and is frequently resistant to numerous therapeutics; thus, safe and effective drugs are needed to combat this disease. Previous studies have demonstrated that triptolide (TPL) exhibits antic
Publikováno v:
Molecular Medicine Reports
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes, which importantly contributes to the increased mortality of patients with diabetes. The development of DCM is accompanied by numerous pathological mechanisms, including oxidative st
Autor:
Yichao Wang, Yang Li, Qianqian Liu, Guangyao Song, Luping Ren, He Zhang, Liying Yang, Shuchun Chen
Publikováno v:
Molecular Medicine Reports
Silibinin is a flavonoid that improves fatty liver and insulin resistance. To elucidate the effect of silibinin on lipid deposition and the potential molecular mechanism, the present study conducted in vivo and in vitro experiments. In the in vivo ex
Publikováno v:
Molecular Medicine Reports
In diabetic animal models, high plasma/tissue levels of methylglyoxal (MG) are implicated in atherosclerosis. N-acetylcysteine (NAC) is a cysteine prodrug that replenishes intracellular glutathione (GSH) levels, which can increase the elimination of
Publikováno v:
Molecular Medicine Reports
Pancreatic and duodenal homeobox (PDX)-1 is a gene that plays an important role in pancreatic development and function. Type-2 diabetes mellitus (T2DM) is a metabolic disease associated with insulin resistance and impaired islet β-cell function. The
Autor:
Noelia Puente‑Moncada, Maria Turos‑Cabal, Carmen Rodríguez, Cristina Duarte‑Olivenza, Ana M. Sánchez‑Sánchez, Federico Herrera, Jezabel Rodriguez‑Blanco, Isaac Antolín, Vanesa Martín
Publikováno v:
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
The FMS‑like tyrosine kinase 3 internal tandem duplication (FLT3‑ITD) mutation represents the most frequent genetic alteration in acute myeloid leukemia (AML) and is associated with poor prognosis. The mutation promotes cancer cell survival and p
Autor:
Liping Hou, Hailong Tang, Yan Yu, Shan Gao, Guangxun Gao, Yaping Zhao, Zhiqiang Tian, Li Xu, Xi Cen, Guang Li, Shuchun Yu, Huafeng Zhu, Juan Feng, Li Yang
Publikováno v:
International Journal of Molecular Medicine
The emergence of new drugs is a major feature of the treatment history of multiple myeloma (MM), which also reflects the current incurability of MM. As a unique member of cyclin dependent kinase (CDK) family, CDK5 participates in numerous tumorigenic