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Publikováno v:
Molecular Medicine Reports
Perioperative neurocognitive dysfunction (PND) is a prevalent neurological complication after anesthesia and surgery. Ginkgolide B (GB) has been suggested to improve lipopolysaccharide‑induced learning and memory impairment. The present study aimed
Autor:
Marcela Cristina Robaina, Gabriela Nestal de Moraes, Gustavo Henrique C. Guimarães, Paulo R. R. Costa, Luciana Mayumi Gutiyama, Luize Otero de Carvalho, Bruna dos Santos Mendonça, Barbara Da Costa Reis Monte‑Mor, Raquel Ciuvalschi Maia, Chaquip D. Netto, Luciano Mazzoccoli, Thaís Hancio, Fernanda Costas Casal de Faria
Publikováno v:
International Journal of Oncology. 58
Acute myeloid leukemia (AML) is a complex hematological disorder characterized by blockage of differentiation and high proliferation rates of myeloid progenitors. Anthracycline and cytarabine‑based therapy has remained the standard treatment for AM
Publikováno v:
Molecular Medicine Reports
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes, which importantly contributes to the increased mortality of patients with diabetes. The development of DCM is accompanied by numerous pathological mechanisms, including oxidative st
Publikováno v:
Molecular Medicine Reports
In diabetic animal models, high plasma/tissue levels of methylglyoxal (MG) are implicated in atherosclerosis. N-acetylcysteine (NAC) is a cysteine prodrug that replenishes intracellular glutathione (GSH) levels, which can increase the elimination of
Publikováno v:
Molecular Medicine Reports
Pancreatic and duodenal homeobox (PDX)-1 is a gene that plays an important role in pancreatic development and function. Type-2 diabetes mellitus (T2DM) is a metabolic disease associated with insulin resistance and impaired islet β-cell function. The
Autor:
Liping Hou, Hailong Tang, Yan Yu, Shan Gao, Guangxun Gao, Yaping Zhao, Zhiqiang Tian, Li Xu, Xi Cen, Guang Li, Shuchun Yu, Huafeng Zhu, Juan Feng, Li Yang
Publikováno v:
International Journal of Molecular Medicine
The emergence of new drugs is a major feature of the treatment history of multiple myeloma (MM), which also reflects the current incurability of MM. As a unique member of cyclin dependent kinase (CDK) family, CDK5 participates in numerous tumorigenic
Autor:
Peijian Tong, Shanxing Zhang, Pinger Wang, Luwei Xiao, Qiang Mao, Hongfeng Ruan, Chengliang Wu, Hongting Jin, Taotao Xu, Yangjun Lao, Li Zhou
Publikováno v:
Molecular Medicine Reports
Long-term administration of glucocorticoid hormones is considered one of predominant pathological factors inducing osteonecrosis of the femoral head (ONFH) development and progression, in which reduction of blood supply leads to a progressive bone lo
Publikováno v:
Molecular Medicine Reports
Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia-induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial fun
Autor:
Ai Harashima, Hiroyuki Tsuchiya, Ryoji Nagai, Jun-ichi Shirakawa, Yasuhiko Yamamoto, Shuhei Ugaji, Seiichi Munesue, Hidenori Matsubara, Takao Aikawa
Publikováno v:
Molecular Medicine Reports. 16:403-409
Patients with diabetes are vulnerable to delayed bone fracture healing or pseudoarthrosis. Chronic sustained hyperglycemia, reactive intermediate derivatives of glucose metabolism, such as methylglyoxal (MGO), and advanced glycation end‑products (A
Autor:
Chelsea Farischon, Dongli Li, Xi Zheng, Susan Goodin, Kun Zhang, Zhiyun Du, Huarong Huang, Yan He
Publikováno v:
Oncology Reports. 37:953-960
Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in hu