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Autor:
Radu Vidra, Snejeana Tintari, Tudor Ciuleanu, Adina Nemes, Andrada Deac, Andreea Vidrean, Sebastian Pintea
Publikováno v:
Experimental and Therapeutic Medicine
The addition of platinum compounds to standard neoadjuvant chemotherapy (NACT) for triple-negative breast cancer (TNBC) is highly controversial. Platinum agents, such as cisplatin and carboplatin, are DNA-damaging agents which exhibit activity in bre
Publikováno v:
International Journal of Molecular Medicine
Simvastatin is effective in the treatment of osteoporosis, partly through the inhibition of the adipogenesis of bone-marrow derived mesenchymal stem cells (BMSCs). The present study focused on the mechanisms responsible for the inhibitory effects of
Autor:
Huali Xu, Guangzhu Lin, Xiaofeng Yu, Hongyan Cao, Guoliang Xu, Dayun Sui, Jianan Geng, Wenwen Fu
Publikováno v:
Experimental and Therapeutic Medicine
The development of abnormal lipid-induced atherosclerosis is initiated with endothelial cell apoptosis. Vascular endothelial cells possess highly developed endoplasmic reticulum (ER), which is involved in lipid metabolism, indicating that ER stress m
Publikováno v:
International Journal of Molecular Medicine
Resveratrol (RSV) and metformin (MET) play a role in the treatment of diabetes; however, the mechanisms through which they mediate insulin resistance by regulating long non-coding RNAs (lncRNAs) remain unknown. The present study was conducted to dete
Autor:
Shuancheng Zhang, Xinping Fu, Jian Yang, Xin Meng, Qingxue Li, Jingwei Chen, Ying Li, Mingli An
Publikováno v:
Experimental and Therapeutic Medicine
Endometriosis (EM), a benign aseptic inflammatory disease, is associated with the presence of endometrial foci. Pain, one of its typical symptoms, has been reported as a constant stressor, but the etiology and pathogenesis of EM-associated pain are u
Autor:
Hirotake Hida, Mariko Nakamura, Yuna Shiroma, Miku Iwata, Akira Yoshimi, Masayuki Miyazaki, Noriko Tanaka, Aya Torii-Goto, Yukihiro Noda, Kiyofumi Yamada
Publikováno v:
Mol Clin Oncol
Chemotherapy-induced nausea and vomiting (CINV) can cause anorexia, weight loss and deterioration of patient quality of life. It is one of the most unpleasant adverse effects of chemotherapy treatment regimens. For the optimal treatment of gastrointe
Publikováno v:
Experimental and Therapeutic Medicine
The aim of the present study was to construct incontinence-associated dermatitis (IAD) rat models and observe the therapeutic effects of zinc oxide, painless skin protective film and silicone dressing on IAD. A total of 54 rats were randomly divided
Publikováno v:
Experimental and Therapeutic Medicine
The Chinese decoction compound centella formula (CCF) is clinically effective against diabetic kidney disease (DKD), but the exact mechanism remains unclear. The present study aimed to investigate the effects of CCF on OxInflammation and silent infor
Publikováno v:
Exp Ther Med
The aim of the study was to explore the efficacy of small-dose ganciclovir on cytomegalovirus infections as well as its effects on the liver function and miR-UL112-3p of children. A total of 141 children infected with cytomegalovirus admitted to the
Autor:
Bianbian Gao, Shuping Sun, Shengli Li, Enze Zhu, Yunyan Du, Rongping Xia, Chao Zhang, Cao Wenjing
Publikováno v:
Experimental and Therapeutic Medicine. 22
Chloranthus serratus is a traditional Chinese medicine for treating arthritis and bruises. The aim of the present study was to investigate the anti-arthritic activities and possible associated mechanisms of different isolated sites of Chloranthus ser