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Publikováno v:
Experimental and Therapeutic Medicine
The Chinese decoction compound centella formula (CCF) is clinically effective against diabetic kidney disease (DKD), but the exact mechanism remains unclear. The present study aimed to investigate the effects of CCF on OxInflammation and silent infor
Autor:
Bianbian Gao, Shuping Sun, Shengli Li, Enze Zhu, Yunyan Du, Rongping Xia, Chao Zhang, Cao Wenjing
Publikováno v:
Experimental and Therapeutic Medicine. 22
Chloranthus serratus is a traditional Chinese medicine for treating arthritis and bruises. The aim of the present study was to investigate the anti-arthritic activities and possible associated mechanisms of different isolated sites of Chloranthus ser
Publikováno v:
Molecular Medicine Reports
In diabetic animal models, high plasma/tissue levels of methylglyoxal (MG) are implicated in atherosclerosis. N-acetylcysteine (NAC) is a cysteine prodrug that replenishes intracellular glutathione (GSH) levels, which can increase the elimination of
Publikováno v:
Experimental and Therapeutic Medicine.
Hyperglycemia-induced oxidative stress and inflammation are hallmarks of liver damage in diabetes mellitus. Accumulating evidence has demonstrated that Pluchea indica leaf ethanol extract (PILE) possesses strong antioxidant and anti-inflammatory prop
Publikováno v:
Experimental and Therapeutic Medicine
Changes of complement and oxidative stress parameters in patients with acute cerebral infarction (ACI) or cerebral hemorrhage (CH), and their clinical significance were explored. A total of 122 patients with ACI or CH admitted to the People's Hospita
Publikováno v:
Experimental and Therapeutic Medicine
The aim of the present study was to investigate the effects of germacrone (GM) and dexmedetomidine (DEX) in treating type 2 diabetes mellitus (T2DM). A high-fat diet (HFD)-induced T2DM rat model was established. The experimental rats were divided int
Publikováno v:
Biomedical Reports. 7:445-450
Streptozotocin (STZ)-induced diabetic rats (STZ rats) were used to investigate diabetic cataracts. In the current study, a shotgun liquid chromatography (LC)/mass spectrometry (MS)-based global proteomic analysis method was used to examine the mechan
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to investigate the effects of hydrogen sulfide (H2S) on the activity and expression of inducible nitric oxide synthase (iNOS) in the myocardial tissue of type 1 diabetic rats. Rats were divided randomly into four grou
Autor:
Hao Wang, Qian Cai, Wei-da Lu, Baoying Li, Haiqing Gao, Fei Yu, Weidong Qin, Zhen Zhang, Mei Yin, Mei Cheng, Pei Zhang
Publikováno v:
Molecular Medicine Reports. 16:2844-2850
Diabetes is commonly associated with liver lipid metabolism disorders. AMP-activated protein kinase (AMPK) has a key role in regulating lipid metabolism. Grape seed procyanidin B2 (GSPB2), a natural polyphenol polymer, ameliorates mitochondrial dysfu
Publikováno v:
Molecular Medicine Reports
Methamphetamine (MA) abuse is a major public health and safety concern throughout the world and a growing burden on healthcare costs. The purpose of the present study was to investigate the protective effect of fluoxetine against MA‑induced chronic