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Autor:
Bianbian Gao, Shuping Sun, Shengli Li, Enze Zhu, Yunyan Du, Rongping Xia, Chao Zhang, Cao Wenjing
Publikováno v:
Experimental and Therapeutic Medicine. 22
Chloranthus serratus is a traditional Chinese medicine for treating arthritis and bruises. The aim of the present study was to investigate the anti-arthritic activities and possible associated mechanisms of different isolated sites of Chloranthus ser
Autor:
Daisuke Motoyama, Atsushi Otsuka, Hiromitsu Watanabe, Keita Tamura, Takayuki Sugiyama, Hideaki Miyake, Toshiki Ito, Yuto Matsushita
Publikováno v:
Molecular and Clinical Oncology.
The aim of the present study was to investigate the impact of the combined use of corticosteroid on adverse events (AEs) induced by enzalutamide (Enz) in patients with metastatic castration-resistant prostate cancer (mCRPC). The cohort of the present
Autor:
Mieko Yanagisawa, Koh Furugaki, Kaname Yamamoto, Masamichi Sugimoto, Mitsue Kurasawa, Keigo Yorozu, Nobuyuki Ishikura, Chinami Masuda, Toshiki Iwai
Publikováno v:
International Journal of Oncology
Erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), shows superior efficacy in patients with non-small cell lung cancer (NSCLC) harboring activating EGFR mutations (EGFR Mut+). However, almost all tumors eventually
Publikováno v:
International Journal of Molecular Medicine. 39:749-756
Proprotein convertase subtilisin/kexin type 9 (PCSK9) impedes low‑density lipoprotein (LDL) receptor (LDLR)-mediated LDL-cholesterol uptake and has hence emerged as a critical regulator of serum cholesterol levels and a new therapeutic target for t
Publikováno v:
International Journal of Molecular Medicine
The lack of circulating epinephrine (EPI) in the pathogenesis of asthma has long been attributed to the lack of adrenergic nerves in human airways. However, in this study we considered that EPI levels are regulated by EPI release in addition to synth
Autor:
Hiroshi Nokihara, Emi Kubo, Yasushi Goto, Noboru Yamamoto, Yuichiro Ohe, Hidehito Horinouchi, Shintaro Kanda, Yutaka Fujiwara
Publikováno v:
Molecular and Clinical Oncology. 6:56-62
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib was initially approved in Japan in 2002 for the treatment of advanced or metastatic non-small-cell lung cancer (NSCLC); however, the optimal order of conventional cytotox
Publikováno v:
Experimental and Therapeutic Medicine. 12:3583-3588
Postoperative pain is a critical problem in clinical pain administration. Due to the unclear formation mechanism of postoperative pain, the treatment of postoperative pain is still in the symptomatic treatment stage and lacking satisfactory analgesic
Publikováno v:
Molecular Medicine Reports.
Previous studies have demonstrated that ovariectomy may lead to a reduction in antioxidative biomarkers in the myocardium, thus suggesting that estrogens may serve a protective role in the suppression of oxidative stress. Lycium barbarum polysacchari
Autor:
Xinchen Wu, Mengqi Zhang
Publikováno v:
Experimental and Therapeutic Medicine.
Osteoporosis is liable to affect patients with gonadal hormone deficiency, and a supplement of androgens may be used to increase bone density of patients with osteoporosis. Since the androgens currently used may cause severe side effects, it is usefu
Autor:
Ningxia Zhang, Hongying Zhang, Baojun Liu, Meng Yang, Jingcheng Dong, Yijie Du, Weiyi Gong, Xiao Wu, Yan Zhang, Xiaoqiang Liang
Publikováno v:
Biomedical Reports
The aim of the study was to examine the mechanism of action of Lidan Granule (LDG) for the prevention of gallstones using a guinea pig model. One hundred guinea pigs were divided into five groups randomly: control (standard diet and saline), model [l