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Publikováno v:
Oncology Reports.
Breast cancer is the leading cause of cancer‑-associated deaths in women. Combination immunotherapy attracts great interest as a treatment for breast cancer. However, there are no studies on the use of cytotoxic T‑lymphocyte antigen 4 (CTLA‑4)
Autor:
Hideyuki Ohzawa, Yoshinori Hosoya, Akira Saito, Yuki Kimura, Yuko Kumagai, Joji Kitayama, Hironori Yamaguchi, Alan Kawarai Lefor, Naohiro Sata
Publikováno v:
Oncology Reports
The peritoneal surface is the most frequent site of metastasis disease in patients with gastric cancer. Even after curative surgery and adjuvant chemotherapy, peritoneal recurrences often develop. Exosomes play pivotal roles in tumor metastasis via t
Autor:
Chang Xu, Chen Liu, Bin Yi, Miao Han, Jing‑Yu Li, Xiaoqing Jiang, Hao Qin, Bin Li, Dadong Zhang, Fugen Li, Zhizhen Li, Qingbao Cheng, Yong Yu, Lei Xiong, Zhiquan Qiu, Feiling Feng
Publikováno v:
Oncology Reports
Targeted therapy based on specific genetic alterations has been proven to be an effective treatment for various types of cancer. In the present study, we aimed to explore the efficacy of personalized targeted therapy guided by targeted deep sequencin
Autor:
Dongmin Chang, Jia Ma, Xin Zhang, Qingnuo Zeng, Bin Hou, Jianhui Li, Zhao Liu, Wenhan Li, Peng Xia
Publikováno v:
Oncology Reports
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the fourth leading cause of cancer‑related mortality worldwide. Thus, identification of the mechanisms involved in the progression of CRC has become a crucial element of facili
Autor:
Xiaomei Zhang, Yibin Jia, Cong Wang, Bin Yao, Nana Wang, Bingxu Tan, Qingxu Song, Zhu-Long Liu, Yufeng Cheng, Jianbo Wang
Publikováno v:
Molecular Medicine Reports
Abnormal paired box 9 (PAX9) expression is associated with tumorigenesis, cancer development, invasion and metastasis. The present study investigated the prognostic significance of PAX9 in esophageal squamous cell carcinoma (ESCC) and its role in pre
Autor:
Takayuki Asao, Takeo Takahashi, Kyoji Ogoshi, Masahiko Motegi, Yosuke Takakusagi, Hiroyuki Kuwano, Hisanori Shoji
Publikováno v:
Oncology Reports
The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present
Publikováno v:
Molecular Medicine Reports
Head and neck squamous cell carcinoma (HNSCC) remains one of the most common malignancies associated with poor prognosis. DNA methylation has emerged as an important mechanism underlying the radio‑resistance of tumors. Prognostic biomarkers based o
Autor:
Wei-Ming Duan, Xin‑Xin Ge, Meng‑Dan Xu, Kai Chen, Meng‑Yao Wu, Wenyu Zhu, Min Tao, Wenjie Wang, Qiaoming Zhi, Fei‑Ran Gong, Jing Wu, Liu‑Mei Shou
Publikováno v:
Molecular Medicine Reports.
The count and classification of white blood cells (WBCs) may be used as prognostic markers in certain types of cancer. The present study investigated the prognostic potential of the counts of WBCs, including lymphocytes (LYs), monocytes (MOs), neutro
Autor:
Junji Akagi, Hideo Baba
Publikováno v:
Oncology Reports.
Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in pati
Publikováno v:
Oncology Reports.
Alanine serine cysteine‑preferring transporter 2 (ASCT2; also known as SLC1A5) is an important glutamine transporter, and it serves a crucial role in tumor growth and progression. ASCT2 is highly expressed in numerous types of cancer, but the patho