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Autor:
Dongxia Wang, Peng Lin, Xing Li, Min Jia, Danying Li, Wen Qiu, Bingxuan Yang, Lili Xu, Bijia Su, Lijun Mo, Hongwei Li, Jinlong Li, Zhongxin Zhou, Jiaxu Ying
Publikováno v:
Oncology Reports
Bladder cancer is a common tumor type of the urinary system, which has high levels of morbidity and mortality. The first‑line treatment is cisplatin‑based combination chemotherapy, but a significant proportion of patients relapse due to the devel
Publikováno v:
International Journal of Molecular Medicine
Melatonin, secreted in a typical diurnal rhythm pattern, has been reported to prevent osteoporosis; however, its role in osteoclastogenesis remains unclear. In the present study, the ability of melatonin to inhibit receptor activator of nuclear facto
Publikováno v:
International Journal of Molecular Medicine
Previous studies have reported that long non‑coding (lnc) RNA FGD5‑antisense 1 (FGD5‑AS1) promotes tumor proliferation, migration and invasion. Therefore, the present study aimed to elucidate the biological role and underlying molecular mechani
Publikováno v:
Oncology Reports
Erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is widely used in the treatment of non‑small cell lung cancer (NSCLC). However, erlotinib resistance leads to high mortality in patients with NSCLC, while the ac
Autor:
Hui Lv, Yi Gao, Yi‑Xin Du, Qian Liu, Marion Schneider, Sheng‑Sheng Liu, Lei Ye, Zi‑Jian Song, Song‑Guo Li, Wei‑Dong Du, Jian Hong
Publikováno v:
Molecular Medicine Reports
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe disease characterized by immune hyperactivation and cytokine storm. Given the high mortality rate of HLH, there is a need for more effective diagnostic tools and treatments. The present st
Autor:
Hyung-Don Kim, Eunyoung Tak, Tae Won Kim, Young-Ra Cho, Jeong Eun Kim, Yong Sang Hong, Chloe Soohyun Jang, Jihun Kim, Minhee Kim, Sueun Choi, Buhm Han, Sun Young Kim
Publikováno v:
Oncology Reports
Neurofibromin 1 (NF1) is a tumor suppressor that has been previously reported to regulate RAS-MAPK signaling. The present study investigated the possible relationship between NF1 expression and anti-EGFR antibody (cetuximab) sensitivity in colorectal
Publikováno v:
Molecular Medicine Reports
Cataract is a blinding‑caused disease and affects millions of individuals worldwide. Although conventional phacoemulsification (CPCS) has been widely used for treatment of cataract, the incidence of cataract‑caused blindness still increased year
Publikováno v:
Molecular Medicine Reports
The purpose of the present study was to explore the potential molecular signaling pathway mediated by the statin rosuvastatin in cultured human coronary artery endothelial cells (HCAECs) induced by CoCl2. CoCl2 was used to induce the apoptosis of HCA
Autor:
Lihui Zhang, Ming Gao, Songyun Zhang, Lijun Liu, Yaxing Kang, Xiaqing Luan, Changhui Qu, Hongyan Li
Publikováno v:
International Journal of Molecular Medicine. 46:1239-1248
Diabetes‑associated cognitive decline is a recently identified a potential complication of diabetes. The present study was designed to examine the effects of troxerutin, a potent antioxidant, on cognitive function in rats with streptozotocin‑indu
Autor:
Satoshi Ikeda, Masato Asaoka, Tomohisa Baba, Takashi Ogura, Koji Okudela, Eri Hagiwara, Yozo Sato, Shigeru Komatsu, Ryota Otoshi, Akimasa Sekine
Publikováno v:
Molecular and Clinical Oncology
The present report describes a case of a 68-year-old male patient with epidermal growth factor receptor (EGFR)-mutant non-small cell lung carcinoma (NSCLC). After cytotoxic chemotherapy of three regimens following 22 months of treatment with EGFR-tyr