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Autor:
Yichao Wang, Yang Li, Qianqian Liu, Guangyao Song, Luping Ren, He Zhang, Liying Yang, Shuchun Chen
Publikováno v:
Molecular Medicine Reports
Silibinin is a flavonoid that improves fatty liver and insulin resistance. To elucidate the effect of silibinin on lipid deposition and the potential molecular mechanism, the present study conducted in vivo and in vitro experiments. In the in vivo ex
Autor:
Minchao Yan, Gang Zhang, Zhaoning Ji, Xiaojun Guo, Hui Zeng, Xiaoyan Zhao, Xiaohui Gao, Yuan Li, Haibing Wu
Publikováno v:
Oncology Letters
T cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematological cancer; however, there is a lack of effective chemotherapeutic or targeted drugs for the treatment of T-ALL. Decitabine is a DNA demethylation agent but it has not been
Publikováno v:
Molecular and Clinical Oncology
Little is known concerning causal factors associated with the size and echogenicity of hepatic hemangiomas. The aim of the present study was to investigate the associations between tumor size and echo pattern and coagulation factors, and to elucidate
Publikováno v:
Oncology Letters
Hepatocellular carcinoma (HCC) is difficult to diagnose at an early stage, and its prognosis is generally poor. Sorafenib is the primary treatment for unresectable advanced HCC and targets multiple receptor tyrosine kinases. However, sorafenib only e
Publikováno v:
Experimental and Therapeutic Medicine
The present study aimed to investigate the preventive effects of Ginkgo biloba leaf extract (GBE) against extracellular matrix (ECM) accumulation in a streptozotocin (STZ)-induced rat model of diabetic nephropathy (DN), and to determine its underlyin
Publikováno v:
Exp Ther Med
A cytokine storm is an uncontrolled, excessive immune response that contributes to the pathogenesis of coronavirus disease 2019 (COVID-19). Viral infections lead to the loss of negative feedback in immune regulation and an abnormal elevation of the l
Publikováno v:
Oncology Letters
Cisplatin resistance is one of the main causes of chemotherapy failure and tumor progression in non-small cell lung cancer (NSCLC). Emodin has been demonstrated to induce NSCLC cell apoptosis and act as a potential cancer therapeutic agent. However,
Autor:
Jung-Soon Han, Woo-Jae Park
Publikováno v:
Molecular Medicine Reports
Inflammation and the inflammasome complex formation are associated with numerous diseases, and palmitates or lipopolysaccharides (LPS) have been identified as potential links between these disorders. Recently, edible insects such as the Gryllus bimac
Publikováno v:
Molecular Medicine Reports
In diabetic animal models, high plasma/tissue levels of methylglyoxal (MG) are implicated in atherosclerosis. N-acetylcysteine (NAC) is a cysteine prodrug that replenishes intracellular glutathione (GSH) levels, which can increase the elimination of
Publikováno v:
International Journal of Molecular Medicine
Osteoarthritis is the most prevalent joint degenerative disease and has been considered a major cause of severe joint pain and physical disability in the elderly. The chondrocyte is the only cell type found in articular cartilage and chondrocyte sene