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Publikováno v:
Molecular Medicine Reports
The purpose of the present study was to explore the potential molecular signaling pathway mediated by the statin rosuvastatin in cultured human coronary artery endothelial cells (HCAECs) induced by CoCl2. CoCl2 was used to induce the apoptosis of HCA
Autor:
Lihui Zhang, Ming Gao, Songyun Zhang, Lijun Liu, Yaxing Kang, Xiaqing Luan, Changhui Qu, Hongyan Li
Publikováno v:
International Journal of Molecular Medicine. 46:1239-1248
Diabetes‑associated cognitive decline is a recently identified a potential complication of diabetes. The present study was designed to examine the effects of troxerutin, a potent antioxidant, on cognitive function in rats with streptozotocin‑indu
Publikováno v:
International Journal of Molecular Medicine
Simvastatin is effective in the treatment of osteoporosis, partly through the inhibition of the adipogenesis of bone-marrow derived mesenchymal stem cells (BMSCs). The present study focused on the mechanisms responsible for the inhibitory effects of
Publikováno v:
Molecular Medicine Reports
Carbenoxolone (CBX) is primarily used to relieve various types of neuropathic and inflammatory pain. However, little is known concerning the role of CBX in acute pain and its functional mechanisms therein and this was investigated in the present stud
Publikováno v:
Molecular Medicine Reports
Endotoxin lipopolysaccharide (LPS) is one of the primary causes of myocardial injury. Propofol confers protective effects against LPS‑induced myocardial damage; however, the biological functions and mechanisms underlying propofol are not completely
Publikováno v:
Molecular Medicine Reports
Diazoxide post‑conditioning (D‑Post) has been shown to be effective in alleviating myocardial ischemia/reperfusion (I/R) injury; however, the specific mechanisms are not fully understood. In the present study, isolated rat hearts were subjected t
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to investigate the antioxidant mechanisms of dexmedetomidine against lung injury during intestinal ischemia reperfusion (IIR) in rats. The model of IIR-induced acute lung injury was established by occluding the superi
Autor:
Han‑Mei Wei, Hong Nie, Chang‑Jian Li, Zi‑Jun Zhao, Jun Zhao, He‑Kun Zeng, Xin Yang, Li‑Na Long, Guo‑Yan Hu
Publikováno v:
Molecular Medicine Reports
Oxidative stress is a pathophysiological condition resulting in neurotoxicity, which is possibly associated with neurodegenerative disorders. In this study, the antioxidative effects of the antioxidant astaxanthin (AXT) in combination with huperzine
Publikováno v:
International Journal of Molecular Medicine.
Anesthetic preconditioning (APC) may decrease the myocardium injury nearly 50% following ischemia/reperfusion (I/R) by enhancing recovery of cardiac function, reducing myocardial enzyme release and lowering infarct size when utilized as pretreatment
Publikováno v:
Molecular Medicine Reports
Dendritic cells (DCs) have an important role in initiating and maintaining the immune inflammatory response in allergic asthma, and CC chemokine receptor 7 (CCR7) is directly involved in the pathogenesis of DC‑ and T cell‑mediated allergic asthma