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Autor:
Ai Wang, Zhong-Shuang Zhang, Xin-Zhi Li, Ke-Tao Ma, Jun-Qiang Si, Liang Zhang, Li Li, He Zhu, Hai-chao Zhang
Publikováno v:
International Journal of Molecular Medicine
Chronic inflammation promotes the development of hypertension and is associated with increased T cell infiltration and cytokine production in impaired organs. Gap junction protein connexin 43 (Cx43), is ubiquitously expressed in immune cells and play
Publikováno v:
Molecular Medicine Reports. 12:6323-6329
Nuclear respiratory factor‑2α (NRF‑2α) is an important transcription factor that regulates mitochondrial oxidative phosphorylation and regeneration. NRF‑2α regulates mitochondrial transcription factors (mTF)A and B, and mitochondrial DNA by
Publikováno v:
Molecular Medicine Reports
Hepatocyte apoptosis and energy metabolism in mitochondria have an important role in the mechanism of acute liver failure (ALF). However, data on the association between apoptosis and the energy metabolism of hepatocytes are lacking. The current stud
Publikováno v:
Molecular Medicine Reports. 12:2953-2960
The aim of the present study was to investigate the differences in the expression of hippocampal proteins between normal control aged rats and aged rats with postoperative cognitive dysfunction (POCD). A total of 24 aged rats were randomly divided in
Autor:
Huachuan Zhang, Tuanyu Fang, Zhaohui Lv, Yanming Chen, Yongyi Gao, Huibiao Quan, Daoxiong Chen
Publikováno v:
Molecular Medicine Reports. 10:2447-2452
Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous disorder affecting >220 million individuals worldwide; this is projected to reach 366 million by 2030. Exenatide, a long‑acting glucagon‑like peptide 1 receptor agonist, exhibits pote
Publikováno v:
Molecular Medicine Reports. 10:2191-2197
Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a newly identified member of the adipocytokine family, whose precise role in chondrocyte metabolism remains to be elucidated. The aim of the present study was to investigate the ef
Publikováno v:
Molecular Medicine Reports. 10:701-706
Hepatic ischemia reperfusion (HI/R) injury may occur during liver transplantation and remains a serious concern in clinical practice. Huperzine A (HupA), an alkaloid isolated from the Chinese traditional medicine Huperzia serrata, has been demonstrat
Publikováno v:
Molecular Medicine Reports. 9:2227-2232
The anti-angina agent nicorandil has been reported to be beneficial even in patients who have angina with diabetes. However, the mechanism underlying the effect of nicorandil in patients with diabetes remains to be elucidated. In this study, the prot
Publikováno v:
Molecular Medicine Reports. 9:985-988
Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. The aim of the present study was to investigate the role of P‑glycoprotein in the transport of dauricine across the blood‑brain barrier by pre‑treat
Autor:
Yulin Deng, Hong-Mei Li, Michael Schläppi, Ling-Yan Meng, Nian Xin, Yujuan Li, Bing-Jie Xie, De-Wei Song
Publikováno v:
International Journal of Molecular Medicine. 33:736-742
There are statistical data indicating that diabetes is a risk factor for Parkinson's disease (PD). Methylglyoxal (MG), a biologically reactive byproduct of glucose metabolism, the levels of which have been shown to be increase in diabetes, reacts wit