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Autor:
Yuki Sakamoto, Souichi Yanamoto, Hiroki Tsuchihashi, Masahiro Umeda, Mitsuko Tokuhisa, Tomofumi Naruse, Kohei Okuyama
Publikováno v:
Oncology Letters
Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatm
Autor:
Peijian Tong, Shanxing Zhang, Pinger Wang, Luwei Xiao, Qiang Mao, Hongfeng Ruan, Chengliang Wu, Hongting Jin, Taotao Xu, Yangjun Lao, Li Zhou
Publikováno v:
Molecular Medicine Reports
Long-term administration of glucocorticoid hormones is considered one of predominant pathological factors inducing osteonecrosis of the femoral head (ONFH) development and progression, in which reduction of blood supply leads to a progressive bone lo
Autor:
Jiaqiang Zhang, Wei Zhang
Publikováno v:
Experimental and Therapeutic Medicine
The present study aimed to evaluate the role of autophagy in the protective effect of dexmedetomidine in lung injury caused by ischemia-reperfusion (IR) in rats. In total 48 adult male Sprague-Dawley rats were randomly divided into 6 groups (n=8) as
Autor:
Yuji Tada, Koichiro Tatsumi, Yuichi Takiguchi, Shunichiro Iwasawa, Tsukasa Ishiwata, Ryota Kurimoto, Takahiro Ebata
Publikováno v:
Oncology Letters. 14:944-950
The epithelial-to-mesenchymal transition (EMT) in cancer is associated with invasion, metastasis and chemoresistance. Recent studies have revealed the increased expression of programmed death-ligand 1 (PD-L1) in cells undergoing EMT. The underlying m
Publikováno v:
Oncology Reports. 37:2016-2024
Furanodiene is one of the major bioactive components isolated from the natural product of the plant, Curcuma wenyujin Y.H. Chen et C. Ling. Furanodiene has been found to exert anticancer effects in various types of cancer cell lines, as well as exhib
Autor:
Ou Zeng, Chun Chu, Zining Li, Fang Li, Biao Liang, Yan Li, Jun Yang, Ting Xiao, Maojun Liu, Lin Li
Publikováno v:
Molecular Medicine Reports
The present study aimed to explore the effect of hydrogen sulfide (H2S) on renal tissue fibrosis and its mechanism in diabetic rats. Rats were randomly divided into four groups (n=13/group): Control group; induced diabetes mellitus group (STZ); induc
Autor:
Xinlian Deng, Jingliang Zhang
Publikováno v:
Experimental and Therapeutic Medicine. 13:1074-1080
The pain induced by local acute inflammation results in mild to severe discomfort, in addition to the possibility of physiological dysfunction and psychiatric disorders, such as sleep disorders and depression. However, the pathogenesis of pain is yet
Autor:
Lu Bai, Wei Ma, Guohong Cai, Shengxi Wu, Jing Yang, Huang-Hui Wu, Si-Xiang Zeng, Chi-Hua Guo, Xin Wang
Publikováno v:
Oncology Reports. 37:249-258
Analgesic strategy of a single drug analgesia in bone cancer pain (BCP) has shifted to combined analgesia with different drugs which have different mechanism. After tumor cell inculation, the activation of signal transducer and activator of transcrip
Publikováno v:
Molecular Medicine Reports. 14:5217-5222
Cerebral venous sinus thrombosis (CVST) is a distinct cerebrovascular disorder, and ~50% of CVST patients progress to cerebral venous infarction, resulting in elevation of cerebral venous pressure. Anticoagulation is the standard initial treatment an
Publikováno v:
Molecular Medicine Reports
Trimetazidine is a piperazine-derived metabolic agent, which exerts cell protective effects and has been reported to be efficient in the treatment of chronic stable angina pectoris. In addition, it has been shown to exert protection against acute myo