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Publikováno v:
Molecular Medicine Reports
The purpose of the present study was to explore the potential molecular signaling pathway mediated by the statin rosuvastatin in cultured human coronary artery endothelial cells (HCAECs) induced by CoCl2. CoCl2 was used to induce the apoptosis of HCA
Publikováno v:
Molecular Medicine Reports
Carbenoxolone (CBX) is primarily used to relieve various types of neuropathic and inflammatory pain. However, little is known concerning the role of CBX in acute pain and its functional mechanisms therein and this was investigated in the present stud
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to investigate the antioxidant mechanisms of dexmedetomidine against lung injury during intestinal ischemia reperfusion (IIR) in rats. The model of IIR-induced acute lung injury was established by occluding the superi
Publikováno v:
International Journal of Molecular Medicine
Trichostatin A (TSA), a histone deacetylase inhibitor, is widely used as an anticancer drug. Recently, TSA has been shown to exert a protective effect on ischemia/reperfusion (I/R) injury; however, the underlying mechanisms remain unclear. Forkhead b
Autor:
Junjiang Chen, Lianqun Cui, Songcun Zhang, Hongjun Sang, Qingjiang Liu, Jingliang Yuan, Rongmei Ma, Lianfeng Shan
Publikováno v:
Molecular Medicine Reports. 16:4791-4796
The present study aimed to investigate whether diminazene attenuates myocardial infarction (MI) in rats. In addition, the present study investigated whether ACE2 signaling was involved in the effects of diminazene on protein function. A rat model of
Autor:
Ling Li, Wanli Zhang, Yu Huang, Lingxiang Chen, Xiaobin Ren, Huazhen Luo, Mingzhu Zhang, Hongbing He
Publikováno v:
Molecular Medicine Reports
The traditional Chinese medicine Yunnan Baiyao (YNB) has been reported to possess anti-inflammatory properties, however its mechanism of action remains unclear. It was previously reported that YNB ameliorated depression of arachidonic acid (AA) level
Publikováno v:
Molecular Medicine Reports. 16:2179-2184
Epoxyeicosatrienoic acid (EET) has wide applications due to the unique biological effects of anti‑hyperlipidemia, inhibition of platelet aggregation, anti‑inflammation, anti‑cancer, anti‑lipid oxidation and the promotion of brain tissue devel
Publikováno v:
Molecular Medicine Reports. 14:5217-5222
Cerebral venous sinus thrombosis (CVST) is a distinct cerebrovascular disorder, and ~50% of CVST patients progress to cerebral venous infarction, resulting in elevation of cerebral venous pressure. Anticoagulation is the standard initial treatment an
Publikováno v:
Molecular Medicine Reports
Trimetazidine is a piperazine-derived metabolic agent, which exerts cell protective effects and has been reported to be efficient in the treatment of chronic stable angina pectoris. In addition, it has been shown to exert protection against acute myo
Autor:
Cunzao Wu, Minmin Wu, Yong Cai, Peng Xia, Ling Zhang, Bicheng Chen, Jiao Luo, Yunqiang He, Xuehai Chen
Publikováno v:
International Journal of Molecular Medicine.
Post‑transplantation diabetes mellitus (PTDM) is a known side effect in transplant recipients administered with immunosuppressant drugs, such as tacrolimus (Tac). Although injury of islet cells is considered a major reason for Tac‑induced PTDM, t