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Autor:
Lihui Zhang, Ming Gao, Songyun Zhang, Lijun Liu, Yaxing Kang, Xiaqing Luan, Changhui Qu, Hongyan Li
Publikováno v:
International Journal of Molecular Medicine. 46:1239-1248
Diabetes‑associated cognitive decline is a recently identified a potential complication of diabetes. The present study was designed to examine the effects of troxerutin, a potent antioxidant, on cognitive function in rats with streptozotocin‑indu
Autor:
Ou Zeng, Chun Chu, Zining Li, Fang Li, Biao Liang, Yan Li, Jun Yang, Ting Xiao, Maojun Liu, Lin Li
Publikováno v:
Molecular Medicine Reports
The present study aimed to explore the effect of hydrogen sulfide (H2S) on renal tissue fibrosis and its mechanism in diabetic rats. Rats were randomly divided into four groups (n=13/group): Control group; induced diabetes mellitus group (STZ); induc
Autor:
Cunzao Wu, Minmin Wu, Yong Cai, Peng Xia, Ling Zhang, Bicheng Chen, Jiao Luo, Yunqiang He, Xuehai Chen
Publikováno v:
International Journal of Molecular Medicine.
Post‑transplantation diabetes mellitus (PTDM) is a known side effect in transplant recipients administered with immunosuppressant drugs, such as tacrolimus (Tac). Although injury of islet cells is considered a major reason for Tac‑induced PTDM, t
Publikováno v:
Molecular Medicine Reports.
Diabetic muscle atrophy causes a reduction of skeletal muscle size and strength, which affects normal daily activities. However, pulsed electromagnetic fields (PEMFs) can retard the atrophy of type II fibers (ActRIIB) in denervated muscles. Therefore
Autor:
Yiling Si, Zihui Deng, Chen Yang, Guanghui Chen, Weidong Han, Liyuan Jin, Jiejie Liu, Huiyan Xu, Jinying Zhang, Haijing Song
Publikováno v:
Molecular Medicine Reports.
It is widely accepted that infusion of mesenchymal stem cells (MSCs) ameliorates hyperglycemia by alleviating insulin resistance in rats with type 2 diabetes mellitus (T2D). However, the detailed underlying mechanisms are not clearly defined. Mitsugu
Autor:
Cheng Chih Chung, Shin‑Yi Tsao, Wen‑Chih Tsai, Yao Chang Chen, Ting I. Lee, Ting Wei Lee, Yu Hsun Kao, Kuan Jen Bai
Publikováno v:
Molecular Medicine Reports.
Autophagy serves a role in preserving cellular homeostasis. Diabetes mellitus (DM) impairs cardiac autophagy and is associated with an accumulation of cytotoxic proteins that may provoke apoptosis and damage cardiomyocytes. Histone deacetylase (HDAC)
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to determine the effects of curcumin on antioxidants using a rat model of type 1 diabetes. Seven‑week‑old male Sprague‑Dawley rats were injected with Streptozotocin (STZ) intraperitoneally to induce this model,
Publikováno v:
Molecular Medicine Reports. 9:2227-2232
The anti-angina agent nicorandil has been reported to be beneficial even in patients who have angina with diabetes. However, the mechanism underlying the effect of nicorandil in patients with diabetes remains to be elucidated. In this study, the prot
Autor:
Yulin Deng, Hong-Mei Li, Michael Schläppi, Ling-Yan Meng, Nian Xin, Yujuan Li, Bing-Jie Xie, De-Wei Song
Publikováno v:
International Journal of Molecular Medicine. 33:736-742
There are statistical data indicating that diabetes is a risk factor for Parkinson's disease (PD). Methylglyoxal (MG), a biologically reactive byproduct of glucose metabolism, the levels of which have been shown to be increase in diabetes, reacts wit
Autor:
Wen-Juan Wu, Bi Tang, Qin Gao, Yang Tang, Hong-Wei Ye, Zhenghong Li, Hongju Wang, Pinfang Kang, Qiang-Qiang Pan
Publikováno v:
Molecular Medicine Reports. 8:686-690
The aim of the present study was to determine the changes in mitochondrial aldehyde dehydrogenase 2 (ALDH2) activity in relation to oxidative stress and inflammatory injury in different stages of diabetes mellitus (DM) in rats and to investigate the