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Publikováno v:
International Journal of Molecular Medicine
Sphingosine-1-phosphate (S1P) serves an important role in various physiological and pathophysiological processes, including the regulation of cell apoptosis, proliferation and survival. Sphingosine kinase 1 (SPHK1) is a lipid kinase that phosphorylat
Publikováno v:
Oncology Letters
Drug resistance hinders effectiveness of human ovarian cancer (OC) therapies, such as cisplatin or paclitaxel therapy. Although dacomitinib, a novel anticancer agent is used against multiple types of cancers, such as non-small cell lung cancer, head
Autor:
Yanying Zhong, Fang Xu, Fuyin Le, Qi Zuo, Xingwu Wu, Jiao Cheng, Xiali Zhang, Buzhen Tan, Chen Luo
Publikováno v:
Oncology Reports
Advanced and recurrent ovarian cancer has a poor prognosis and is frequently resistant to numerous therapeutics; thus, safe and effective drugs are needed to combat this disease. Previous studies have demonstrated that triptolide (TPL) exhibits antic
Publikováno v:
Oncology Letters
Cisplatin resistance is one of the main causes of chemotherapy failure and tumor progression in non-small cell lung cancer (NSCLC). Emodin has been demonstrated to induce NSCLC cell apoptosis and act as a potential cancer therapeutic agent. However,
Autor:
Shuiliang Wang, Wencui Kong, Wenwu Wang, Xiaoming Ling, Zongyang Yu, Xiaoli Wu, Zhongquan Zhao, Guoxiang Lai, Ying Chen
Publikováno v:
International Journal of Molecular Medicine
Lung cancer is the leading cause of cancer‑associated mortality worldwide. Cisplatin (DDP) is a first‑line chemotherapeutic drug for the treatment of lung cancer; however, the majority of patients develop resistance to DDP. P‑glycoprotein (P‑
Publikováno v:
Oncology Letters. 12:4195-4202
Platinum compounds, such as cisplatin, carboplatin, oxaliplatin and nedaplatin, are widely used to treat a number of solid malignancies. Nedaplatin is a second-generation platinum complex, based on its pronounced anti-cancer activities against severa
Autor:
Denisa Margina, Valentina Anuta, Octavian Tudorel Olaru, Aristidis Tsatsakis, Demetrios A. Spandidos, George Mihai Nitulescu, Cristina Dinu Pirvu, Oana Cristina Seremet, Anca Zanfirescu, Georgiana Nitulescu
Publikováno v:
International Journal of Molecular Medicine
The use of alternative techniques to reduce the number of animals used in anticancer research is an issue of current interest. The aim of this study was to validate the use of a simple and efficient alternative tool for the assessment of the potentia
Autor:
Wei Zhou, Yixian Jing, Xiaolan Yang, Xiaolei Hu, Mingyue Zou, Fei Liao, Jinpeng Lu, Xin Wang, Bangtian Xu, Tingting Tong, Lei Xi
Publikováno v:
Oncology Reports.
The roles of glutathione S‑transferase pi 1 (GSTP1), glutathione S‑transferase mu 2 (GSTM2) and glutathione S‑transferase alpha 1 (GSTA1) in cisplatin (DDP)‑resistance of solid cancer cells (A549/DDP, SKOV3/DDP and SGC7901/DDP) were compared
Publikováno v:
Experimental and Therapeutic Medicine. 10:2277-2282
Hydrogen has been reported to exert a therapeutic effect in several diseases due to its antioxidative, anti-inflammatory and anti-apoptotic properties. The aim of the present study was to investigate whether hydrogen-rich saline treatment could atten
Publikováno v:
Oncology Letters.
The aim of the present study was to determine whether acetazolamide (Ace) treatment enhances the chemosensitivity of Hep-2 laryngeal cells to cisplatin (Cis). At the logarithmic growth phase, Hep-2 cells were treated with Ace, Cis or both, and cell v