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Publikováno v:
Experimental and Therapeutic Medicine
Chemoresistance of colorectal cancer (CRC) leads to tumor recurrence and metastasis and new strategies are urgently needed to improve the outcomes of conventional chemotherapy. Sirtuin (SIRT) inhibitors prevent tumor cell growth by increasing the lev
Publikováno v:
Experimental and Therapeutic Medicine
Human epidermal growth factor receptor 2 (HER2) is reported to be overexpressed in breast cancers and is associated with poor clinical outcome. Trastuzumab is a humanized anti-HER2 antibody that offers significant survival benefits to patients with H
Publikováno v:
Molecular Medicine Reports
Carbenoxolone (CBX) is primarily used to relieve various types of neuropathic and inflammatory pain. However, little is known concerning the role of CBX in acute pain and its functional mechanisms therein and this was investigated in the present stud
Publikováno v:
Oncology Letters
Hepatocellular carcinoma (HCC) is difficult to diagnose at an early stage, and its prognosis is generally poor. Sorafenib is the primary treatment for unresectable advanced HCC and targets multiple receptor tyrosine kinases. However, sorafenib only e
Publikováno v:
Exp Ther Med
A thorough understanding of the inflammatory process has substantial biological and clinical relevance. Para-inflammation has been described as an adaptive response of the immune system to low levels of tissue stress. However, the role of para-inflam
Publikováno v:
Experimental and Therapeutic Medicine.
The objective of the present study was to explore the role of hepatocyte growth factor (HGF) in directing treatment of Mycoplasma pneumoniae pneumonia (MP). Serum levels of HGF were assessed using ELISA in 65 pediatric patients with MP, 42 with bacte
Autor:
Pingping Zhou, Sun Hao, Hongwei Liu, Martha‑Spyridoula Katsarou, Jian Zhang, Nikolaos Drakoulis
Publikováno v:
Experimental and Therapeutic Medicine.
Conjunctivitis associated systemic lupus erythematosus (caSLE) is a connective tissue autoimmune disease with a large spectrum of clinical manifestations. The disease may lead to ocular complications and in severe cases may be sight-threatening. This
Autor:
Mieko Yanagisawa, Koh Furugaki, Kaname Yamamoto, Masamichi Sugimoto, Mitsue Kurasawa, Keigo Yorozu, Nobuyuki Ishikura, Chinami Masuda, Toshiki Iwai
Publikováno v:
International Journal of Oncology
Erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), shows superior efficacy in patients with non-small cell lung cancer (NSCLC) harboring activating EGFR mutations (EGFR Mut+). However, almost all tumors eventually
Autor:
Haruo Iguchi, Kimihiko Matsusue, Soichi Takiguchi, Norihiro Teramoto, Kazuko Inoue, Masayuki Furukawa
Publikováno v:
International Journal of Oncology. 51:184-192
Peritoneal dissemination is a frequent occurrence in pancreatic cancer, which is associated with a poor prognosis. MET is associated with the progression of pancreatic cancer; therefore, we evaluated the effect of a MET inhibitor, crizotinib, on peri
Autor:
Hui Wang, Zhiwei Feng, Junnian Zheng, Huijie Jia, Yali Xiao, Minming Li, Wenjing Ren, Qian Cheng, Chen Li, Yuchen Feng, Tiesuo Zhao
Publikováno v:
Oncology Reports. 37:3405-3414
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with a poor prognosis and high mortality. At present, vaccination with tumor cell lysate (TCL) loaded dendritic cells (DC) has been shown to be an effective therapy against HCC. However