Zobrazeno 1 - 10
of 229
pro vyhledávání: '"11"'
Autor:
Jimin Yang, Jae Yeon Jeong, Eun Ju Lee, Woo Jean Kim, Hyoung Oh Jun, Kyeong Won Lee, Sae Won Lee
Publikováno v:
Oncology Reports. 34:2745-2751
Low oxygen or hypoxia can be observed in the central region of solid tumors. Hypoxia is a strong stimulus for new blood vessel formation or angiogenesis, which is essential for tumor growth and progression. Fibroblast growth factor 11 (FGF11) is an i
Publikováno v:
Oncology Reports. 34:1415-1423
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, mainly due to its high rates of postoperative recurrence and metastasis. Moreover, there is no widely accepted prognostic marker of recurrence. Therefore, the aim of
Autor:
Atsumi Sano, Michio Nakamura, Takafumi Sangai, Takahiro Hasebe, Hiroyuki Maeda, Atsushi Ochiai
Publikováno v:
International Journal of Oncology.
Expression of human kallikrein 11 (hK11), secreted as a trypsin-like serine protease, is related to the prognosis of some human cancers, but its physiological functions in the steps of cancer progression are still unknown. In order to elucidate the e
Autor:
Ayumi Yoshizaki, Kazuyuki Yamazumi, Toshiyuki Nakayama, Ichiro Sekine, Mitsuru Taba, Yuichi Yakata
Publikováno v:
International Journal of Oncology.
Previous investigations have shown that interleukin (IL)-11/IL-11 receptor alpha-chain (IL-11Ralpha), a member of the PI3K, MAPK and JAK-STAT activating family of cytokines/receptors, correlates with the regulation of tumor progression. In this study
Publikováno v:
Oncology Reports.
Arsenic trioxide (As 2 O 3 ) has been used as an effective chemotherapy agent for some human cancer, such as acute promyelocytic leukemia. We have demonstrated that low level of As 2 O 3 relatively selectively inhibited growth of the solid tumor MGC-
Autor:
Rong Wang, Keliang Huang
Publikováno v:
Molecular Medicine Reports
CD4+ regulatory T (Treg) cells are associated with immune tolerance and antitumor immunosuppression. The aim of the present study was to investigate the role and molecular mechanism of C‑C motif chemokine ligand 11 (CCL11) in the regulation of Treg
Publikováno v:
International Journal of Oncology. 51:1191-1198
Tamoxifen resistance is a major clinical challenge in breast cancer treatment. Our previous studies find that GPER and its down-stream signaling play a pivotal role in the development of tamoxifen (TAM) resistance. cDNA array analysis indicated a set
Autor:
Wen Zhong, Guohua Zeng, Tao Zhang, Hui-chan He, Wei-de Zhong, Xiaolu Duan, Junhong Fan, Chao Cai, Wenqi Wu, Tuo Deng, Zanlin Mai, Yongda Liu
Publikováno v:
Oncology Reports
hsa-miR-195-5p (miR-195) has been proven to be a critical regulator in the progression of prostate cancer (PCa). To identify additional targets and molecular functions of miR-195, we overexpressed miR-195 by transient oligonucleotide transfection in
Publikováno v:
International Journal of Oncology.
Renal cell carcinoma (RCC) with t(6;11) translocation has been characterized by the fusion of the Alpha gene with the TFEB gene. However, the underlying molecular mechanisms remain greatly uncharacterized and effective targeted therapy has yet to be
Autor:
Jie Chen, Jinku Bao, Hailian Wang, Ping Qi, Tongyu Li, Wei Shi, Yi Wang, Wenchun Jiang, Xin Li, Guodong Huang, Chunyang Li
Publikováno v:
International Journal of Oncology. 50:823-834
Computational drug repositioning by virtually screening existing drugs for additional therapeutic usage could efficiently accelerate anticancer drug discovery. Herein, a library of 1447 Food and Drug Administration (FDA)-approved small molecule drugs