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Publikováno v:
Molecular Medicine Reports. 22:1583-1593
α‑naphthylisothiocyanate (ANIT) is used to induce intrahepatic cholestasis and it is frequently used for investigations into the disease mechanism. The lithocholic acid (LCA) cholestatic model has also been extensively used in various studies; how
Autor:
Erwei Hao, Hailian Wang, Tiantian Lei, Wang Zhiping, Minghan Sun, Yi Wang, Jiagang Deng, Jianzhen Lv, Wen Xiong, Xiaoqi Huang, Shaoping Deng
Publikováno v:
Molecular Medicine Reports
Previous studies have demonstrated that regulatory T cells (Tregs) are pivotal in the regulation of T cell-mediated immune responses in atherosclerosis, a chronic autoimmune-like disease. In the authors' previous studies, it was demonstrated that amy
Publikováno v:
Molecular Medicine Reports. 15:2814-2822
A high‑fat diet or high‑cholesterol diet (HCD) is a major cause of metabolic diseases, including obesity and diabetes; vascular diseases, including hypertension, stroke and arteriosclerosis; and liver diseases, including hepatic steatosis and cir
Autor:
Yanman Zhou, Qingbo Guan, Hongqiang Zhao, Haiqing Zhang, Shanshan Shao, Jin Xu, Meng Zhao, Tuo Deng, Chunxiao Yu
Publikováno v:
Molecular Medicine Reports
As the incidence of osteoporosis (OP) and hypercholesterolaemia in men has increased, male OP has drawn more attention from clinicians worldwide. The present study sought to investigate the effects of cholesterol on male bone. Between July 2015 and O
Autor:
Chen Feng, Yong Zhou, Xiang‑Ying Meng, Jian‑Yang Chen, Li‑Ming Liu, Li Wei, Wei‑Wei Ye, Yi Wang, Qian Xiao
Publikováno v:
Molecular Medicine Reports. 14:3293-3300
Angiopoietin-like protein 4 (Angptl4) is a secreted protein predominantly expressed in liver and adipose tissues, and has been identified as an adipokine. Angptl4 is the target gene of peroxisome proliferator‑activated receptors, which are widely u
Publikováno v:
Molecular Medicine Reports
Obesity may induce end‑organ damage through metabolic syndrome, and autophagy serves a vital role in the pathogenesis of metabolic syndrome. The purpose of the present study was to define the roles of autophagy and mitophagy in high fat diet (HFD)
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to establish a non-alcoholic fatty liver disease (NAFLD) model using cholesterol-fed rabbits and to investigate whether endoplasmic reticulum stress (ERS) serves a role in the pathogenesis of NAFLD. A total of 20 male
Publikováno v:
Molecular Medicine Reports. 12:2907-2911
Cholelithiasis is a common medical condition whose incidence rate is increasing yearly, while its pathogenesis has yet to be elucidated. The present study assessed the expression of Rho-kinase (ROCK) in gallbladder smooth muscles and its effect on th
Publikováno v:
Molecular Medicine Reports. 11:3976-3980
Hyperlipidemia is considered an independent risk factor for renal dysfunction and induces a significant increase in the expression of inflammatory mediators, which can be used to evaluate the degree of renal injury. Baicalin is widely used in traditi
Publikováno v:
Molecular Medicine Reports. 11:561-566
Robinetinidol-(4β,2')-tetrahydroxy-flavone (RBF) is an oligomeric condensed polyphenol that has been shown to exhibit anti-obesity effects in mice. However, little is know regarding its effect on cholesterol synthesis. The present study therefore ai