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Publikováno v:
Experimental and Therapeutic Medicine
The aim of the present study was to investigate the effect of rutin treatment on the expression of glycogen synthase kinase (GSK)-3β and tumor necrosis factor (TNF)-α in A549 human lung carcinoma cells. The A549 cells were divided into control, cis
Autor:
Takuya Fujiwara, Miaki Uzu, Hiromi Sato, Koichi Ueno, Tatsuro Kashiba, Hiroko Okuzawa, Rina Suzuki
Publikováno v:
Oncology Letters. 14:937-943
Sunitinib (SU) is a small molecule that inhibits the receptor tyrosine kinase (RTK) signaling pathway, and has been clinically used to treat advanced renal cell carcinoma (RCC). However, SU is not always effective as RCC is a highly chemoresistant ty
Autor:
Yuji Tada, Koichiro Tatsumi, Yuichi Takiguchi, Shunichiro Iwasawa, Tsukasa Ishiwata, Ryota Kurimoto, Takahiro Ebata
Publikováno v:
Oncology Letters. 14:944-950
The epithelial-to-mesenchymal transition (EMT) in cancer is associated with invasion, metastasis and chemoresistance. Recent studies have revealed the increased expression of programmed death-ligand 1 (PD-L1) in cells undergoing EMT. The underlying m
Publikováno v:
Oncology Letters
Sorafenib is a multikinase inhibitor and is effective in treating hepatocellular carcinoma (HCC). However, it remains unknown whether sorafenib induces the alteration of protein glycosylation. The present study treated HCC MHCC97L and MHCC97H cells w
Autor:
Toshikage Nagao, Shinya Ishida, Gaku Oshikawa, Masahide Yamamoto, Keisuke Tanaka, Hiroki Akiyama, Osamu Miura
Publikováno v:
Oncology Letters
The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which r
Publikováno v:
Molecular Medicine Reports
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage and respiratory failure. ALI and ARDS result are associated with high mortality in patients. At present, no effective treatme
Autor:
Xiao‑Lin Tong, Yu‑Yu Jiang, Fang Yang, Meng‑Meng Dang, Han‑Ming Cui, Jian‑Tao Kou, Jia‑Long Wang, Hui Liu, Qiu‑Yan Zhang
Publikováno v:
Molecular Medicine Reports. 16:6981-6991
The aim of the present study was to compare the different effects of berberine (Ber) and Coptischinensis extract (CCE) on a rat model of type 2 diabetes mellitus (T2DM), and the islet Rin‑5f cell line was used to examine the differences between Ber
Publikováno v:
Molecular and Clinical Oncology. 6:955-959
The purpose of this study was to assess the incidence of tumor lysis syndrome (TLS) in patients with hematological malignancies treated with rasburicase, and to evaluate the dose and duration of rasburicase administration. A total of 52 patients were
Publikováno v:
Experimental and Therapeutic Medicine
Treatment of infantile hemangiomas (IH) with propranolol was first reported in 2008. Regressions of lymphatic malformations combined with pulmonary hypertension was first reported in 2012 after three children received treatment with oral sildenafil,
Autor:
Jin Park, Seol Hwa Shin, Si Yeol Song, Jung Jin Hwang, Seung-Mo Hong, Eun Jin Ju, Seong-Yun Jeong, Shun'ich Kuroda, Eun Kyung Choi, Eun Jeong Ko, Joohee Jung, Kyoung Jin Lee, Jung Shin Lee, Seok Soon Park
Publikováno v:
Oncology Reports. 38:2259-2266
The incidence of hepatocellular carcinoma (HCC) has continued to increase worldwide, and advanced HCC is difficult to treat using the currently available therapeutics. Chemoradiotherapy with cisplatin (cis-diamminedichloroplatinum, CDDP) is expected