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Publikováno v:
International Journal of Molecular Medicine
Simvastatin is effective in the treatment of osteoporosis, partly through the inhibition of the adipogenesis of bone-marrow derived mesenchymal stem cells (BMSCs). The present study focused on the mechanisms responsible for the inhibitory effects of
Autor:
Huali Xu, Guangzhu Lin, Xiaofeng Yu, Hongyan Cao, Guoliang Xu, Dayun Sui, Jianan Geng, Wenwen Fu
Publikováno v:
Experimental and Therapeutic Medicine
The development of abnormal lipid-induced atherosclerosis is initiated with endothelial cell apoptosis. Vascular endothelial cells possess highly developed endoplasmic reticulum (ER), which is involved in lipid metabolism, indicating that ER stress m
Autor:
Yuguo Zhang, Ling-bo Kong, Suxian Zhao, Wei-guang Ren, Yuemin Nan, Rongqi Wang, Wencong Li, Qing-Shan Zhang
Publikováno v:
Experimental and Therapeutic Medicine
Non-alcoholic steatohepatitis (NASH) has no approved therapy. The farnesoid X nuclear receptor (FXR) agonist obeticholic acid (OCA) has shown promise as a drug for NASH, but can adversely affect plasma lipid profiles. Therefore, the present study aim
Publikováno v:
Experimental and Therapeutic Medicine. 22
Emerging evidence indicates that exposure to fine particulate matter contributes to the onset of diabetes. The present study aimed to investigate the mechanism of particulate matters (PM)2.5 affecting glucose homeostasis in mice with type 1 diabetes
Autor:
Gui-Lin Song, Li-Chen Dong, Sayed Ali Sheikh, Hai-Qing Hu, Zhong-Bao Yang, Tao-Ming Li, Yu-Xian Zhu, Li Mao, Mei-Ling Zuo
Publikováno v:
Biomedical Reports
An increase in liver gluconeogenesis is an important pathological phenomenon in type 2 diabetes mellitus (T2DM) and oxymatrine is an effective natural drug used for T2DM treatment. The present study aimed to explore the effect of oxymatrine on glucon
Publikováno v:
Oncology Letters
Hepatocellular carcinoma (HCC) has an increasing incidence worldwide, and the global 5-year survival rate ranges from 5–30%. In China, HCC seriously threatens the nation's health; the incidence of HCC ranks fourth among all theriomas, and the morta
Severe hypoglycaemia under abemaciclib administration in a patient with breast cancer: A case report
Autor:
Minekazu Yamaguchi, Shingo Yamagata, Shigeru Sakano, Miyako Horie, Kazutaka Kurokohchi, Tsunetaka Kijima, Kazunari Ishitobi, Satoshi Honda, Tatsuo Horie
Publikováno v:
Molecular and Clinical Oncology
The current study reports the case of an 80-year-old woman who experienced severe hypoglycaemia after abemaciclib administration, with a recovery time of ~46 h. Abemaciclib is a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor that is used to treat
Publikováno v:
Molecular Medicine Reports
In diabetic animal models, high plasma/tissue levels of methylglyoxal (MG) are implicated in atherosclerosis. N-acetylcysteine (NAC) is a cysteine prodrug that replenishes intracellular glutathione (GSH) levels, which can increase the elimination of
Publikováno v:
Molecular Medicine Reports
Pancreatic and duodenal homeobox (PDX)-1 is a gene that plays an important role in pancreatic development and function. Type-2 diabetes mellitus (T2DM) is a metabolic disease associated with insulin resistance and impaired islet β-cell function. The
Autor:
Atsushi Suetsugu, Nobuhiko Nakamura, Takao Miwa, Kenji Imai, Koji Takai, Makoto Shiraki, Yoshikazu Ikoma, Junichi Kitagawa, Hiroyasu Sakai, Masahito Shimizu, Yohei Shirakami, Tatsunori Hanai, Nobuhiro Kanemura
Publikováno v:
Molecular and Clinical Oncology
Recently, treatments for chronic hepatitis C virus (HCV) infection have significantly improved by the development of direct-acting antiviral agents (DAAs) and almost all patients with HCV can complete antiviral treatment without apparent adverse even