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pro vyhledávání: '"Thomas C. Foster"'
Publikováno v:
J Neurosci
Age-related cognitive impairments are associated with differentially expressed genes (DEGs) linked to defined neural systems; however, studies examining multiple regions of the hippocampus fail to find links between behavior and transcription in the
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
The Journal of Neuroscience. 33:15710-15715
NMDA receptors (NMDARs) play a critical role in learning and memory; however, there is a lack of evidence for a direct relationship between a well characterized decline in NMDAR function and impaired cognition during aging. The present study was desi
Autor:
Kristina K. Aenlle, Thomas C. Foster, Asha Rani, Xiaoxia Han, Ashok Kumar, Linda A. Bean, Susan L. Semple-Rowland
Publikováno v:
The Journal of Neuroscience. 33:2671-2683
The expression of the ERα and ERβ estrogen receptors in the hippocampus may be important in the etiology of age-related cognitive decline. To examine the role of ERα and ERβ in regulating transcription and learning, ovariectomized wild-type (WT)
Autor:
Thomas C. Foster, Philip W. Landfield, Kuey-Chu Chen, Nada M. Porter, Keith M Sharrow, James P. Herman, Eric M. Blalock
Publikováno v:
The Journal of Neuroscience. 23:3807-3819
Gene expression microarrays provide a powerful new tool for studying complex processes such as brain aging. However, inferences from microarray data are often hindered by multiple comparisons, small sample sizes, and uncertain relationships to functi