Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sarah Zohar"'
Autor:
Thomas Hamborg, Siew Wan Hee, Martin Posch, Nigel Stallard, Sarah Zohar, Simon Day, Frank Miller, Jason Madan
Publikováno v:
Statistical Methods in Medical Research
Statistical Methods in Medical Research, SAGE Publications, 2016, 25 (3), pp.1022-1038. ⟨10.1177/0962280215588245⟩
Statistical Methods in Medical Research, SAGE Publications, 2016, 25 (3), pp.1022-1038. ⟨10.1177/0962280215588245⟩
Pilot studies and other small clinical trials are often conducted but serve a variety of purposes and there is little consensus on their design. One paradigm that has been suggested for the design of such studies is Bayesian decision theory. In this
Publikováno v:
Clinical Trials. 10:414-421
Background The Continual Reassessment Method typically is presented as the method of choice for the purpose of dose-finding based on a toxicity scale in phase I clinical trials. However, this adaptive statistical approach also can be applied easily t
Publikováno v:
Clinical Trials. 8:370-379
Background Toxicity grades underlie the definition of a dose-limiting toxicity but in the majority of phase I designs, the information contained in the individual grades is not used. Some authors have argued that it may be more appropriate to conside
Publikováno v:
Clinical Trials. 5:595-606
Background In non-cancer phase II trials, dose-finding trials are usually carried out using fixed designs, in which several doses including a placebo are randomly distributed to patients. However, in certain vulnerable populations, such as neonates o
Autor:
Boulet S; Inria, HeKA, Paris, France.; INSERM, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Paris, France., Ursino M; Inria, HeKA, Paris, France.; INSERM, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Paris, France.; Unit of Clinical Epidemiology, Assistance Publique - Hopitaux de Paris, CHU Robert Debré, INSERM CIC-EC 1426, Paris, France., Michelet R; Department of Clinical Pharmacy & Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany., Aulin LB; Department of Clinical Pharmacy & Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany., Kloft C; Department of Clinical Pharmacy & Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany., Comets E; INSERM, Univ Rennes, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMRS 1085, Rennes, France.; INSERM, Université Paris Cité, IAME, Paris, France Sandrine Boulet and Moreno Ursino made equal contributions and are co-first authors. Emmanuelle Comets and Sarah Zohar made equal contributions and are co-last authors., Zohar S; Inria, HeKA, Paris, France.; INSERM, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Paris, France.
Publikováno v:
Statistical methods in medical research [Stat Methods Med Res] 2024 Apr; Vol. 33 (4), pp. 574-588. Date of Electronic Publication: 2024 Mar 06.