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Publikováno v:
World Journal for Pediatric and Congenital Heart Surgery. 13:16-22
Background: Pediatric cardiothoracic surgery has evolved over the last several decades with shorter bypass times and less need for hypothermic arrest. Diuretics have been commonly used in the post-operative period with no guidelines on duration follo
Publikováno v:
J Cereb Blood Flow Metab
Ischemic tolerance is a phenomenon whereby transient exposure to a non-injurious preconditioning stimulus triggers resistance to a subsequent lethal ischemic insult. Despite the fact that not only neurons but also astrocytes and endothelial cells hav
Autor:
Christoph C. Eschenfelder, Anika Hüsing, Marcus Brinkmann, Christian Weimar, Andreas Stang, Gerrit M. Grosse, Hans-Christoph Diener, Nils Kuklik
Publikováno v:
European Stroke Journal. 6:438-444
Background The optimal timing of anticoagulation following acute ischaemic stroke or TIA in patients with atrial fibrillation (AF) is a frequent challenge. Early initiation of anticoagulation can reduce the risk for recurrent ischaemic events, but ma
Publikováno v:
Seminars in Cardiothoracic and Vascular Anesthesia. 26:41-53
Acute decompensated heart failure (ADHF) in pediatrics is a significant cause for morbidity and mortality in children. Congenital heart disease and cardiomyopathy are the leading etiologies of ADHF. It is common for these children to undergo diagnost
Autor:
Jorge E. Jalil, María Paz Ocaranza, Ulises Novoa, David Mondaca-Ruff, Italo Mora, Patricio Araos, Cristian Yañez
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 26:724-735
Background: Thiazides are one of the most common antihypertensive drugs used for hypertension treatment and hydrochlorothiazide (HCTZ) is the most frequently used diuretic for hypertension treatment. The Rho/Rho-kinase (ROCK) path plays a key functio
Publikováno v:
Perfusion. 38:270-276
Background: Levosimendan (LEVO) is a positive inotropic drug which could increase myocardial contractility and reduce the mortality rate in cardiac surgical patients. However, Whether LEVO is associated with postoperative bleeding and blood transfusi
Autor:
T J Bunch, David B. Min, Heidi T May, Raymond O McCubrey, Stacey Knight, Michael J. Cutler, Jeffrey L. Anderson, Kirk U. Knowlton, Steve Mason, Joseph B. Muhlestein, Viet T Le
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 26:648-655
Background: Flecainide is a useful antiarrhythmic for atrial fibrillation (AF). However, because of ventricular proarrhythmia risk, a history of myocardial infarction (MI) or coronary artery disease (CAD) is a flecainide exclusion, and stress testing
Autor:
David J. Douin, Kenji Tanabe, Ana Fernandez-Bustamante, Martin Krause, Adit A. Ginde, Karsten Bartels, Cynthia Williams, Aurora N Quaye
Publikováno v:
Seminars in Cardiothoracic and Vascular Anesthesia. 26:32-40
Objective Recent clinical trials confirmed the corticosteroid dexamethasone as an effective treatment for patients with COVID-19 requiring mechanical ventilation. However, limited attention has been given to potential adverse effects of corticosteroi
Publikováno v:
Vascular Medicine (London, England)
Abdominal aortic aneurysm (AAA) is an important vascular disease carrying significant mortality implications due to the risk of aneurysm rupture. Current management relies exclusively on surgical repair as there is no effective medical therapy. A key
Publikováno v:
Seminars in Cardiothoracic and Vascular Anesthesia
Persistent postoperative pain (PPP) after cardiac surgery is a significant complication that negatively affects patient quality of life and increases health care system burden. However, there are no standards or guidelines to inform how to mitigate t