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Publikováno v:
Lupus. 30:1849-1855
Progressive multifocal leukoencephalopathy (PML) is one of the rare but lethal infectious complication in patients with SLE, manifesting progressive central nervous demyelination caused by JC virus (JCV). There have been no effective antiviral agents
Autor:
A Hugo Montes, Guadalupe Martin, Eulalia Valle-Garay, José A. Carton, Alvaro Meana, Victoria Alvarez, Julio Collazos, Francisco Taboada, Laura Pérez-Is, Victor Asensi
Publikováno v:
Innate Immunity. 27:409-420
Primary responses in sepsis-mediated inflammation are regulated by pro-inflammatory cytokines. Variations in the cytokine genes might modify their transcription or expression, plasma cytokines levels and response to sepsis. Activation protein-1 (AP-1
Publikováno v:
Lupus. 30:1671-1678
Introduction Activation of the complement pathway by immune complexes is a key feature of systemic lupus erythematosus (SLE) and SLE glomerulonephritis, which translates into low levels of C3 and C4 during active disease. C3 glomerulonephritis (C3GN)
Autor:
Asaf Wilensky, A Laviv, Gabriel Mizraji, Oded Heyman, Y Horev, Lior Shapira, H Sharawi, Avi-Hai Hovav, Simon Yona
Publikováno v:
Journal of Dental Research. 100:1330-1336
As the most potent cells activating and polarizing naive T cells, dendritic cells (DCs) are of major importance in the induction of immunity and tolerance. DCs are a heterogeneous population of antigen-presenting cells that are widely distributed in
Publikováno v:
Experimental Biology and Medicine
Acute respiratory disease caused by a novel coronavirus (SARS-CoV-2) has spread all over the world, since its discovery in 2019, Wuhan, China. This disease is called COVID-19 and already killed over 1 million people worldwide. The clinical symptoms i
Publikováno v:
Multiple Sclerosis Journal. 27:2116-2118
Dengue fever (DF) is an endemic infectious disease in tropical and subtropical regions. Ocrelizumab is a humanized monoclonal antibody that targets the CD20 antigen on B cells, which is approved for the treatment of both relapsing-remitting multiple
Autor:
Nicholas Schwab, Tilman Schneider-Hohendorf, Sven G. Meuth, Luisa Klotz, Claudia Janoschka, Catharina C. Gross, Felix Luessi, Andreas Schulte-Mecklenbeck, Heinz Wiendl, Marc Pawlitzki, Patrick Ostkamp, Frauke Zipp
Publikováno v:
Multiple Sclerosis (Houndmills, Basingstoke, England)
Background: Progressive multifocal leukoencephalopathy (PML) can in rare cases occur in natalizumab-treated patients with high serum anti-JCPyV antibodies, hypothetically due to excessive blockade of immune cell migration. Objective: Immune cell recr
Autor:
Daniel da Cruz Bezerra, Antônio Carlos Coutinho, Luiz Celso Hygino da Cruz, F. S. Lima, Diogo Goulart Corrêa
Publikováno v:
Multiple Sclerosis Journal. 27:973-976
Neurologic complications are being recognized as important outcomes of coronavirus disease 2019 (COVID-19). Pathogenesis is varied and incompletely understood, and may include neuroinvasion, indirect post-infectious neuroinflammation, and cerebrovasc
Publikováno v:
J Scleroderma Relat Disord
Eosinophilic fasciitis is a rare connective tissue disease of unknown etiology. Therapeutic options include high-dose corticosteroids and other immunosuppressive drugs. We present a typical eosinophilic fasciitis case, which did not respond to first-
Publikováno v:
Neurohospitalist
Hospital neurologists participate at the forefront of managing fulminant acute and subacute onset epilepsy, frequently attributed to autoimmune encephalitis (AE). As the recognition of antibody-mediated AE grows, there is a growing number of patients