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Autor:
AbdelMoneim M Naguib, Sara M. Mohamed, Tahany A.A. Aly, Emam A. Abdel-Rahim, Marwa S. Khattab
Publikováno v:
Exp Biol Med (Maywood)
Increased environmental pollution and unhealthy lifestyle are blamed for escalated chronic diseases. Exposure to aflatoxins was recently suggested to have a role in the increased incidence of type 2 diabetes mellitus. Diet modification and consumptio
Autor:
Mohamed Ibrahim, Yasmine F. Ibrahim, Maha Y. Kamel, Asmaa Ma Bayoumi, Marwa M.M. Refaie, Sara M Ahmed, Rabab A Moussa
Publikováno v:
Human & Experimental Toxicology. 40:S788-S803
Hepatocellular carcinoma (HCC) accounts for more than 5% of all human cancers. Diacerein (DIA), an interleukin (IL)-1β inhibitor, is used for the treatment of osteoarthritis. DIA is a potential anticancer drug acting on several protein targets in th
Publikováno v:
Human & Experimental Toxicology. 40:S540-S552
Ischemic stroke is a leading cause of death and long-term disability worldwide. The aim of this study is to explore the potential function of ephedrine in ischemic stroke and the underlying molecular mechanism. A middle cerebral artery occlusion (MCA
Publikováno v:
Human & Experimental Toxicology. 40:S487-S496
Diabetic nephropathy is a progressive kidney disease resulting from long-term hyperglycaemia in diabetic patients, and the underlying mechanism is complex and lacks effective treatments. Various active ingredients in Chinese herbs have been shown to
Autor:
Jorge E. Jalil, María Paz Ocaranza, Ulises Novoa, David Mondaca-Ruff, Italo Mora, Patricio Araos, Cristian Yañez
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 26:724-735
Background: Thiazides are one of the most common antihypertensive drugs used for hypertension treatment and hydrochlorothiazide (HCTZ) is the most frequently used diuretic for hypertension treatment. The Rho/Rho-kinase (ROCK) path plays a key functio
Autor:
Evelyn Romero Mateos, Alfredo Cruz Orea, Lilia I. Olvera Cano, Guadalupe Cleva Villanueva López
Publikováno v:
Applied Spectroscopy. 75:1465-1474
According to the World Health Organization, diabetes was the seventh leading cause of death in 2016. Long-term diabetes complications are associated with hyperglycemia. It is difficult to predict the beginning and evolution of those complications. Th
Publikováno v:
Vascular Medicine (London, England)
Abdominal aortic aneurysm (AAA) is an important vascular disease carrying significant mortality implications due to the risk of aneurysm rupture. Current management relies exclusively on surgical repair as there is no effective medical therapy. A key
Autor:
Tung-Yang Yu, Li-Ping Lin, Wen-Chung Tsai, Miao-Sui Lin, Jong-Hwei S. Pang, Hsiang-Ning Chang, Gwo-Jyh Chang
Publikováno v:
The American Journal of Sports Medicine. 49:3102-3112
Background: The increasing use of platelet-rich plasma (PRP) to treat muscle injuries raises concerns because transforming growth factor–beta (TGF-β) in PRP may promote fibrosis in the injured muscle and thus impair muscle regeneration. Purpose: T
Autor:
Di Chang, Shi-Jun Zhang, Chun-Qiang Lu, Yuan-Cheng Wang, Yu Cai, Zhen Zhao, Shenghong Ju, Tingting Xu, Shudan Min
Publikováno v:
Exp Biol Med (Maywood)
Chronic kidney disease (CKD) is a major contributor to the development of heart failure with preserved ejection fraction (HFpEF), whereas the underlying mechanism of cardiorenal HFpEF is still elusive. The aim of this study was to investigate the rol
Publikováno v:
J Psychopharmacol
Background: Choline supplementation (+Ch) improves cognitive function in impaired animals and humans. Chemotherapy-related cognitive deficits (CRCDs) occur in cancer patients, and these deficits persist following treatment, adversely impacting qualit