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Publikováno v:
J Psychopharmacol
Background: Choline supplementation (+Ch) improves cognitive function in impaired animals and humans. Chemotherapy-related cognitive deficits (CRCDs) occur in cancer patients, and these deficits persist following treatment, adversely impacting qualit
Autor:
Anthony Carter, Matthew W. McDonald, Gergely Silasi, Matthew S. Jeffers, Angela Dykes, Ralph Nevins, Dale Corbett, Allyson Ripley
Publikováno v:
Neurorehabilitation and Neural Repair
Remote ischemic conditioning (RIC) is a noninvasive procedure whereby several periods of ischemia are induced in a limb. Although there is growing interest in using RIC to improve stroke recovery, preclinical RIC research has focused exclusively on n
Autor:
Rodopi Stamatiou, Soultana Stravela, Isaac Aidonidis, Vassileios Moschovidis, Konstantina Dipla, Apostolia Hatziefthimiou, Vassileios Simopoulos
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 25:65-71
Ranolazine has been found to prevent ventricular arrhythmias (VAs) during acute myocardial infarction (AMI). This study aimed to investigate its efficacy on VAs induced several days post-MI. For this purpose, 13 anesthetized rabbits underwent coronar
Autor:
Hani Jneid, Mahboob Alam, Glenn N. Levine, Yochai Birnbaum, Dan Atar, Joseph Allencherril, Robert A. Kloner
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 24:215-224
Acute myocardial infarction (MI) is still a large source of morbidity and mortality worldwide. Although early reperfusion therapy has been prioritized in the modern era of percutaneous coronary intervention and thrombolysis, attempts at incremental i
Autor:
Gregory J. Dusting, Karina Huynh, Anh Cao, David M. Kaye, Gemma A. Figtree, Rebecca H. Ritchie, Xiao Jun Du, Mitchel Tate, Tracey L Julius, Minh Deo, Sally G Hood, Helen Kiriazis
Publikováno v:
Diabetes and Vascular Disease Research. 14:423-433
Diabetic cardiomyopathy is a major contributor to the increasing burden of heart failure globally. Effective therapies remain elusive, in part due to the incomplete understanding of the mechanisms underlying diabetes-induced myocardial injury. The ob
Autor:
Liang Jin, Lili Shen, Li Zong, Jie Wu, Guoliang Li, Shiping Lu, Kunfeng Liu, Dongcheng Huang, Rongyue Cao
Publikováno v:
Diabetes and Vascular Disease Research. 14:184-190
Recent studies have investigated the potential of type 1 diabetes mellitus–related autoantigens, such as heat shock protein 60, to induce immunological tolerance or to suppress the immune response. A functional 24-residue peptide derived from heat
Autor:
Erik De Clercq
Publikováno v:
Antiviral Chemistry & Chemotherapy
Antiviral Chemistry & Chemotherapy, Vol 27 (2019)
Antiviral Chemistry & Chemotherapy, Vol 27 (2019)
AMD3100 (plerixafor, Mozobil®) was first identified as an anti-HIV agent specifically active against the T4-lymphotropic HIV strains, as it selectively blocked the CXCR4 receptor. Through interference with the interaction of CXCR4 with its natural l
Publikováno v:
Molecular Pain
Background Cancer pain is a well-known serious complication in metastatic or terminal cancer patients. Current pain management remains unsatisfactory. The activation of spinal and supraspinal P2X7 receptors plays a crucial role in the induction and m
Autor:
Anne-Sophie Ernst, Reiner Kunze, Lexiao Li, Philipp Barteczek, Laura-Inés Böhler, Hugo H. Marti
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:291-306
Hypoxia-inducible factors mediate adaptive responses to ischemia, among others, by induction of anti- and pro-survival genes. Thus, the impact of HIF on neuronal survival upon stroke is controversial. Therefore, neuron-specific knockout mice deficien
Autor:
Qiu Zhang, Chang-jiang Wang, Huan Su, Hai-qin Tang, Wei Wei, Yuan Wang, Qing Zhou, Song-tao Tang, Huaqing Zhu
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 21:82-92
The development of diabetic macrovascular complications is a multifactorial process, and melatonin may possess cardiovascular protective properties. This study was designed to evaluate whether melatonin attenuates arteriosclerosis and endothelial per