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Publikováno v:
Pathobiology. 89:233-244
Background: Long non-coding RNAs are reportedly endowed with the function of promoting or inhibiting cancer occurrence and development. The emphasis of this study was placed on the effect of lncRNA HLA complex group 11 (HCG11) on glioma progression,
Publikováno v:
Pathobiology. 88:289-300
Introduction: Follicular thyroid carcinoma (FTC) is more aggressive than the most common papillary thyroid carcinoma (PTC). However, the current research on FTC is less than PTC. Here, we investigated the effects of long noncoding RNA (lncRNA) GAS5 a
Autor:
Kazuaki Tanabe, Naohiro Uraoka, Hideki Ohdan, Naoya Sakamoto, Narutaka Katsuya, Yuji Yamamoto, Ryuichi Asai, Naohide Oue, Wataru Yasui, Kazuhiro Sentani
Publikováno v:
Pathobiology. 87:254-261
Objectives: Esophageal cancer is the sixth most common malignancy worldwide. Signal peptidase complex 18 (SPC18) protein, which is encoded by the SEC11A gene, is one of the subunits of the signal peptidase complex and plays an important role in the s
Autor:
Yuming Peng, Zhao-Yang Liu, Hong-Qiang Gao, Xin-Yi Sheng, Tian Zhang, Miao-Xian Yuan, Yan-Bing Zhang, Wei-Xin Xie, Qiang Yin, Chun-Yi Ji, Lijian Chen
Publikováno v:
Pathobiology. 87:161-170
Objective: MiR-203 has been shown to participate in multiple malignancies, but the role of miR-203 in hepatoblastoma (HB) remains unclear. The aim of our study was to investigate the effects of miR-203 in HB. Methods: A total of 15 pairs of HB tissue
Publikováno v:
Pathobiology. 87:277-290
Objectives: Scirrhous gastric cancer, which accounts for approximately 10% of all gastric cancers, often disseminates to the peritoneum, leading to intractable cases with poor prognosis. There is an urgent need for new treatment approaches for this d
Publikováno v:
Pathobiology. 87:327-337
Gastric cancer (GC) is a highly prevalent digestive malignant tumor, ranking second in the tumor-related mortality globally. The microRNAs have been confirmed to be connected with GC progression. Accumulative evidence has suggested that miR-6838-5p e
Publikováno v:
Pathobiology. 85:322-331
Objective: This study aims to investigate the mechanism of proliferation potential-related protein (PP-RP) in influencing the proliferation, migration, and apoptosis of esophageal cancer cells. Methods: Quantitative real-time PCR and western blotting
Autor:
Ryuichi Asai, Naohide Oue, Wataru Yasui, Yuji Yamamoto, Naohiro Uraoka, Takashi Oshima, Naoya Sakamoto, Kazuhiro Sentani, Akira Ishikawa
Publikováno v:
Pathobiology. 85:192-200
Objective: Spheroid colony formation is a useful method of cancer stem cell (CSC) characterization. We previously showed that the IQ motif containing the GTPase-activating protein 3 gene (IQGAP3) is upregulated in spheroid body-forming gastric cancer
Autor:
Naohide Oue, Kazuhiro Sentani, Shoichiro Mukai, Takeharu Imai, Masahiro Nishioka, Takashi Oshima, Kazuhiro Yoshida, Naoya Sakamoto, Wataru Yasui, Keisuke Matsusaki
Publikováno v:
Pathobiology. 84:16-24
Objective: Gastric cancer (GC) is one of the most common human cancers. A useful method of gastric cancer stem cell (CSC) characterization is spheroid colony formation. Previously, we reported that KIF11 expression is >2-fold in spheroid-body-forming
Autor:
Marcilei E. Buim, Maíra A. Lima, Suely Nonogaki, João de Jesus Viana Pinheiro, Fernando Augusto Soares, Vanessa Morais Freitas, JA Turri, Joema Felipe Lima, Liliane Oliveira de Lima Amaral dos Santos, Cynthia Aparecida Bueno de Toledo Osório
Publikováno v:
Pathobiology. 83:316-326
Background: ADAMTS are metalloproteases with disintegrin and thrombospondin motifs. They are secreted proteases playing a role in biological processes such as inflammation, angiogenesis, and urogenital development. ADAMTS have specific substrates, su