Zobrazeno 1 - 10
of 16
pro vyhledávání: ''
Autor:
Ximena Castillo, Bibiana Moreno-Carranza, Carmen Clapp, Maria G. Ledesma-Colunga, Xarubet Ruiz-Herrera, Gonzalo Martínez de la Escalera, Edith Arnold, Zesergio Melo, Fernando López-Casillas
Publikováno v:
Neuroendocrinology. 109:152-164
Background: Vasoinhibin, a protein derived from prolactin, regulates various vascular functions including endothelial cell survival. Of note, vasoinhibin is present in the central nervous system, where it triggers neuroendocrine and behavioral respon
Publikováno v:
Neuroendocrinology. 108:121-131
The mitogen-activated protein kinase (MAPK) cascades are central signaling pathways that play a central role in the regulation of most stimulated cellular processes including proliferation, differentiation, stress response and apoptosis. Currently 4
Autor:
Svenja Nölting, Gerald Spoettl, Julian Maurer, Elke Tatjana Aristizabal Prada, Christoph J. Auernhammer
Publikováno v:
Neuroendocrinology. 106:58-73
Background/Aim: Cyclin-dependent kinases (CDKs) are crucial for cell cycle regulation, and alterations in the cell cycle are often observed in human cancer. CDK4/6 in particular orchestrates G1 phase progression and the G1/S transition. Here, we inve
Publikováno v:
Sexual Development. 7:7-20
Sex determination of the gonad is an extraordinary process by which a single organ anlage is directed to form one of two different structures, a testis or an ovary. Morphogenesis of these two organs utilizes many common cellular events; differences i
Autor:
S. L. Griswold, Rischard R. Behringer
Publikováno v:
Sexual Development. 3:1-15
Male sexual differentiation is a complex process requiring the hormone-producing function of somatic cells in the gonad, including Sertoli cells and fetal Leydig cells (FLCs). FLCs are essential for virilization of the male embryo, but despite their
Publikováno v:
Hormone Research in Paediatrics. 59:85-93
We have reported that excessive steroid hormone production in adrenal cortical tumors results from the disordered expression and activity of specific steroidogenic enzymes. Since no genetic mutations in these steroidogenic enzymes have as yet been id
Publikováno v:
Hormone Research in Paediatrics. 57:127-132
Background: We have developed a rapid, sensitive and quantitative in vitro assay for leptin based upon its ability to bind to the soluble extracellular domain of the leptin receptor (sOB-R). Such an assay is theoretically capable of differentiating b
Autor:
Erwin P. Bottinger, Jeffrey B. Kopp
Publikováno v:
Mineral and Electrolyte Metabolism. 24:154-160
Aberrant expression of TGF-β and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-β isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects o
Publikováno v:
Mineral and Electrolyte Metabolism. 24:136-143
Transforming growth factor-beta (TGF-beta) is the prototypic member of a large family of structurally related proteins. Three vertebrate TGF-beta isoforms have been identified and termed TGF-beta1, TGF-beta2, and TGF-beta3, respectively. In addition,
Publikováno v:
Hormone Research in Paediatrics. 50:30-36
To know the biological functions of the adherens junction in uterine endometrium, mRNA expressions of E-cadherin and α- and β-catenin, which mainly comprise the adherens junction, were determined. Furthermore, to understand various functions relate