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Publikováno v:
International Archives of Allergy and Immunology. 182:800-806
Background: The ciliary beat of the airway epithelium, including the sinonasal epithelium, has a significant role in frontline defense and is thought to be controlled by the level of intracellular Ca2+. Involvement of calmodulin and adenylate/guanyla
Autor:
Zhenghai Qu, Zhi-Dong Lv, Mingji Yi, Ni Ran, Yanxia Wang, Shan Yanchun, Xin‐Jie Liu, Zhao‐Chuan Yang
Publikováno v:
International Archives of Allergy and Immunology. 181:239-248
Background: Transforming growth factor-β1 (TGF-β1)-induced proliferation of airway smooth muscle cells plays critical roles in the development of airway remodeling. Six1 (sine oculis homeobox homolog 1) has been demonstrated to be involved in air
Autor:
Asiel Arce-Sillas, Laura Adalid-Peralta, Gladis Fragoso, Edgar Sevilla-Reyes, Marisela Hernández, Citzielli Aseret Pérez-Correa, Edda Sciutto, Carlos Castellanos Barba, Marie-Catherine Boll, Ulises Rodríguez-Ortiz, Graciela Cárdenas, Adrián Guevara-Salinas, Alma Viridiana Vivas-Almazan, Diana Denisse Álvarez-Luquín
Publikováno v:
Neuroimmunomodulation. 26:159-166
Objective: Parkinson’s disease (PD) patients are usually treated with L-dopa and/or dopaminergic agonists, which act by binding five types of dopaminergic receptors (DRD1–DRD5). Peripheral immune cells are known to express dopamine receptors on t
Autor:
Yehuda Shoenfeld, Darja Kanduc
Publikováno v:
Pathobiology. 86:285-295
Objective: To define the cross-reactivity potential and the consequent autoimmunity intrinsic to viral versus human peptide sharing. Methods: Using human papillomavirus (HPV) infection/active immunization as a research model, the experimentally valid
Publikováno v:
Cellular Physiology and Biochemistry, Vol 42, Iss 2, Pp 623-639 (2017)
Background/Aims: Bone marrow Mesenchymal stem cells (MSCs) are promising for promoting cutaneous wound healing through reinforcing cellular processes. We evaluated the effect of GFP-tagged MSCs transplantation on skin regeneration in excisional wound
Autor:
Alfred Ayala, Bethany M. Biron, Jonathan S. Reichner, Xian M. O’Brien, Chun-Shiang Chung, Yaping Chen
Publikováno v:
Journal of Innate Immunity. 9:22-32
Sepsis refers to the presence of a serious infection that correlates with systemic and uncontrolled immune activation. Posttranslational histone modification plays an important role in chromatin decondensation, which is regulated by citrullination. C
Autor:
Alberto García-Redondo, Rosario Osta, Pilar Zaragoza, Samanta Gasco, Amaya Rando, Miriam de la Torre, Janne M. Toivonen
Publikováno v:
Neurodegenerative Diseases. 17:1-13
Background: Amyotrophic lateral sclerosis (ALS) causes loss of upper and lower motor neurons as well as skeletal muscle (SKM) dysfunction and atrophy. SKM is one of the tissues involved in the development of ALS pathology, and studies in a SOD1-G93A
Publikováno v:
Neuroimmunomodulation. 23:224-229
Objective: Activation of STAT1 is directly downstream of the cytokine receptors that signal from specific proinflammatory cytokines known to be dysregulated in schizophrenia (SZ), such as IFNγ, IL6, IL2 and IL10, as well as hypoxia, viral/bacterial
Autor:
Tadashi Ariga, Satoshi Sasaki, Yasuyuki Sato, Takeshi Yamazaki, Takayuki Okamoto, Asako Hayashi
Publikováno v:
Nephron. 134:238-252
Background/Aims: De novo expression of CD44 is considered as a marker of parietal epithelial cell (PEC) activation. The aim of our study was to explore CD74 expression, which can form a complex with CD44, in PECs during the progression of focal segme
Autor:
Junfeng Zhang, Tiantian Zhang, Wenlong Yang, Changqian Wang, Zongqi Zhang, Yizhu Chen, Lingyu Guo
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 2, Pp 423-437 (2016)
Background/Aims: Smooth muscle cells may dedifferentiate into the synthetic phenotype and promote atherosclerosis. Here, we explored the role of myoendothelial gap junctions in phenotypic switching of human coronary artery smooth muscle cells (HCASMC