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Publikováno v:
Oncology. 100:155-162
Introduction: Not only the 21-gene recurrence score (RS) assay but also online prognostic tools and immunohistochemical prognostic models predict chemotherapy benefits for women with early breast cancer (BC). Multigene assays, including Oncotype DX,
Autor:
Hiroyuki Kitano, Naoya Sakamoto, Jun Teishima, Kenichiro Ikeda, Shogo Inoue, Naohide Oue, Kazuhiro Sentani, Xiangrui Han, Kohei Kobatake, Yohei Sekino, Takashi Babasaki, Wataru Yasui, Tetsutaro Hayashi, Go Kobayashi, Akio Matsubara, Shunsuke Miyamoto, Keisuke Goto
Publikováno v:
Oncology. 99:240-250
Introduction: BUB1 mitotic checkpoint serine/threonine kinase B encoded by BUB1B gene is a member of the spindle assembly checkpoint family. Several reports have demonstrated that overexpression of BUB1B is associated with cancer progression and prog
Autor:
Caj Haglund, Tuomas Kaprio, Jaana Hagström, Ines Beilmann-Lehtonen, Karin Strigård, Richard Palmqvist, Ulf-Håkan Stenman, Ulf Gunnarsson, Camilla Böckelman
Publikováno v:
Oncology. 99:790-801
Background: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy globally. CRC patients with elevated plasma C-reactive protein (CRP) levels exhibit compromised prognoses. Toll-like receptors (TLRs), activating the innate and adapt
Autor:
Hye-Won Hwang, Mineui Hong, Yoon Yang Jung, Jung Hoon Lee, Jin Soo Lee, Sook-Hee Hong, Soon Auck Hong
Publikováno v:
Oncology
Background: Sex-determining region Y-box 2 (SOX2) is a transcriptional factor that drives embryonic stem cells to neuroendocrine cells in lung development and is highly expressed in small-cell lung cancer (SCLC). However, the prognostic role of SOX2
Autor:
Alessandra Rubagotti, Elisa Zanardi, Sandra Salvi, Linda Zinoli, Chiara Boccardo, Antonio Di Meglio
Publikováno v:
Oncology Research and Treatment. 43:362-371
Introduction: Our understanding of the granularity of breast cancer (BC) clinical outcomes by biologic subtype may be impaired by limited study follow-up times. Objective: We evaluated the impact of modern immunohistochemistry (IHC)-based BC subtypes
Autor:
Lin Fung Chan, Hiroshi Miyakita, Seiichiro Yamamoto, Toshiyuki Suzuki, Kazutake Okada, Hiroshi Kajiwara, Sotaro Sadahiro
Publikováno v:
Oncology
Background: In patients with colorectal cancer, the rate of recurrence increases as the histologic stage progresses. However, the prediction of recurrence in individual patients is difficult. Many studies have reported on the relation between outcome
Autor:
Yu-Feng Tian, Pei-Ling Hsieh, Ching-Chieh Yang, Chia-Lin Chou, Yow-Ling Shiue, Sung-Wei Lee, Wan-Shan Li, Cheng-Yi Lin
Publikováno v:
Oncology. 98:549-557
Background/Aim: A great proportion of patients with rectal cancer initially present with locally advanced disease and can potentially benefit from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before surgery. However, risk and clini
Publikováno v:
Oncology Research and Treatment. 43:346-353
Introduction: Mammary Paget’s disease (MPD) is a rare cutaneous manifestation. Epidemiologically, more than half of the MPD patients concurrently have underlying invasive ductal carcinoma (MPD-IDC), and their prognosis remains poor despite multimod
Autor:
Shunsuke Miyamoto, Tetsutaro Hayashi, Jun Teishima, Go Kobayashi, Akio Matsubara, Hiroyuki Kitano, Yohei Sekino, Takashi Babasaki, Naohide Oue, Wataru Yasui, Keisuke Goto, Shogo Inoue, Naoya Sakamoto, Xiangrui Han, Kazuhiro Sentani
Publikováno v:
Oncology. 98:689-698
Background: βIII-Tubulin, encoded by the TUBB3 gene, is a microtubule protein. Several studies have shown that overexpression of TUBB3 is linked to poor prognosis and is involved in taxane resistance in some cancers. Objective: The aim of this study
Autor:
Seung Hyun Kim, Kyung Sik Kim, Hyae Min Jeon, Jae Seok Lee, Jin Suck Suh, Hong In Yoon, Hyo Song Kim, Kum Hee Yun, Kyu Hyun Park, Sunghoon Kim, Hyuk Hur, Soo Hee Kim, Min Kyung Jeon, Young Han Lee
Publikováno v:
Oncology. 98:817-826
Background: Developing personalized strategies for cancer has shown good efficacies. Methods: We assessed the molecular targets programmed death ligand 1 (PD-L1), microsatellite instability (MSI), and PIK3CA. Seventy-four patients with liposarcomas w