Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Yuji Oikawa"'
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :19-26
As a right-hand segment with three consecutive chiral centres corresponding to the C-1—C-5 unit of erythromycin A (1), (2S,3R,4S)-3,5-isopropylidenedioxy-2,4-dimethylpentanal (32) was synthesized from D-glucose (5) by application of MPM (4-methoxyb
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1-5
A chiral synthon, 3,6-dideoxy-1,2-O-isopropylidene-3-C-methyl-β-L-lyxo-hexofuranos-5-ulose (7), for the total synthesis of erythromycin A (1) corresponding to both the C-1—C-4 and C-9—C-12 fragments was synthesiszed highly stereoselectively from
Autor:
Osamu Yonemitsu, Yuji Oikawa
Publikováno v:
J. Chem. Soc. D. :555b-556
Under mild conditions the β-oxo-sulphoxide (1) undergoes acid-catalyse rearrangement and cyclization to from naphthalenes.
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :27
In order to prove unequivocally the structures and configurations of the two synthesized segments, (3) and (4), for the synthesis of erythromycin A (1) from D-glucose (2), chemical cleavage of dihydroerythronolide A (5) at the lactone and the 5,6-vic
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :7
For the purpose of the total synthesis of erythromycin A (1) from D-glucose (2) with the aid of stereochemical control in acyclic systems and p-methoxyphenylmethyl (MPM) protection, (2R,3S,4S,5R,6R,7R)-1-hydroxy-5,6-isopropylidenedioxy-3,7-bis(4-meth