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Autor:
Joo-Yeon Engelen-Lee, Federico Iovino, Sandra Muschiol, Arie van der Ende, Merche Valls Seron, Birgitta Henriques-Normark, Matthijs C. Brouwer, Jan Bergstrand, Jerker Widengren, Diederik van de Beek, Peter Mellroth
Publikováno v:
Journal of experimental medicine, 214(6), 1619-1630. Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Pneumococci are major causes of bacterial meningitis. Iovino et al. show that pneumococci invade the brain and pass the blood–brain barrier by interacting with the endothelial receptors pIgR and PECAM-1 recognizing the pneumococcal adhesin RrgA and