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Autor:
Pérez-Moreno, Juan José, Smith, Rebecca C, Oliva, Megan K, Gallo, Filomena, Ojha, Shainy, Müller, Karin H, O'Kane, Cahir J
Neuronal endoplasmic reticulum (ER) appears continuous throughout the cell. Its shape and continuity are influenced by ER-shaping proteins, mutations in which can cause distal axon degeneration in Hereditary Spastic Paraplegia (HSP). We therefore ask
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3aff82dd4d8c179ea9f6293bb52425
https://www.repository.cam.ac.uk/handle/1810/346986
https://www.repository.cam.ac.uk/handle/1810/346986
Autor:
Femmy C. Stempels, Muwei Jiang, Harry M. Warner, Magda-Lena Moser, Maaike H. Janssens, Sjors Maassen, Iris H. Nelen, Rinse de Boer, William F. Jiemy, David Knight, Julian Selley, Ronan O’Cualain, Maksim V. Baranov, Thomas C.Q. Burgers, Roberto Sansevrino, Dragomir Milovanovic, Peter Heeringa, Matthew C. Jones, Rifka Vlijm, Martin ter Beest, Geert van den Bogaart
Publikováno v:
Journal of Cell Biology, 222
Journal of Cell Biology, 222, 7
The journal of cell biology 222(7), e202205130 (2023). doi:10.1083/jcb.202205130
Journal of Cell Biology, 222, 7
The journal of cell biology 222(7), e202205130 (2023). doi:10.1083/jcb.202205130
Contains fulltext : 292891.pdf (Publisher’s version ) (Open Access) Endosomal Sorting Complex Required for Transport (ESCRT) proteins can be transiently recruited to the plasma membrane for membrane repair and formation of extracellular vesicles. H
Autor:
Carla V. Rothlin, Sourav Ghosh
Publikováno v:
Journal of Cell Biology. 222
Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of mac
Autor:
Anna Klucnika, Peiqiang Mu, Jan Jezek, Matthew McCormack, Ying Di, Charles R. Bradshaw, Hansong Ma
Funder: Gurdon Institute Core Facility
Mechanisms that safeguard mitochondrial DNA (mtDNA) limit the accumulation of mutations linked to mitochondrial and age-related diseases. Yet, pathways that repair double-strand breaks (DSBs) in animal mito
Mechanisms that safeguard mitochondrial DNA (mtDNA) limit the accumulation of mutations linked to mitochondrial and age-related diseases. Yet, pathways that repair double-strand breaks (DSBs) in animal mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1de1cb52ef72575674f9c2b29b1d15
https://www.repository.cam.ac.uk/handle/1810/344209
https://www.repository.cam.ac.uk/handle/1810/344209
Autor:
Jean Paul Chadarevian, Sonia I. Lombroso, Graham C. Peet, Jonathan Hasselmann, Christina Tu, Dave E. Marzan, Joia Capocchi, Freddy S. Purnell, Kelsey M. Nemec, Alina Lahian, Adrian Escobar, Whitney England, Sai Chaluvadi, Carleigh A. O’Brien, Fazeela Yaqoob, William H. Aisenberg, Matias Porras-Paniagua, Mariko L. Bennett, Hayk Davtyan, Robert C. Spitale, Mathew Blurton-Jones, F. Chris Bennett
Publikováno v:
The Journal of experimental medicine, vol 220, iss 3
Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and expand the potential for microglia replacement, we engineered an inhibitor-
Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
Autor:
Valérie Van Steenbergen, Laura Burattini, Michelle Trumpp, Julie Fourneau, Almir Aljović, Maryam Chahin, Hanseul Oh, Marta D’Ambra, Florence M. Bareyre
Publikováno v:
Journal of Experimental Medicine. 220
Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to
Autor:
Casey Beppler, John Eichorst, Kyle Marchuk, En Cai, Carlos A. Castellanos, Venkataraman Sriram, Kole T. Roybal, Matthew F. Krummel
Publikováno v:
The Journal of cell biology, vol 222, iss 3
T cells typically recognize their ligands using a defined cell biology—the scanning of their membrane microvilli (MV) to palpate their environment—while that same membrane scaffolds T cell receptors (TCRs) that can signal upon ligand binding. Chi
Autor:
Lévy, Romain, Gothe, Florian, Momenilandi, Mana, Magg, Thomas, Materna, Marie, Peters, Philipp, Raedler, Johannes, Philippot, Quentin, Rack-Hoch, Anita, Langlais, David, Bourgey, Mathieu, Lanz, Anna-Lisa, Ogishi, Masato, Rosain, Jérémie, Martin, Emmanuel, Latour, Sylvain, Vladikine, Natasha, Distefano, Marco, Khan, Taushif, Rapaport, Franck, Schulz, Marian, Holzer, Ursula, Fasth, Anders, Sogkas, Georgios, Speckmann, Carsten, Troilo, Arianna, Bigley, Venetia, Roppelt, Anna, Dinur-Schejter, Yael, Toker, Ori, Bronken Martinsen, Karen, Sherkat, Roya, Somekh, Ido, Somech, Raz, Shouval, Dror, Kühl, Jörn-Sven, Ip, Winnie, Mcdermott, Elizabeth, Cliffe, Lucy, Ozen, Ahmet, Baris, Safa, Rangarajan, Hemalatha, Jouanguy, Emmanuelle, Puel, Anne, Bustamante, Jacinta, Alyanakian, Marie-Alexandra, Fusaro, Mathieu, Wang, Yi, Kong, Xiao-Fei, Cobat, Aurélie, Boutboul, David, Castelle, Martin, Aguilar, Claire, Hermine, Olivier, Cheminant, Morgane, Suarez, Felipe, Yildiran, Alisan, Bousfiha, Aziz, Al-Mousa, Hamoud, Alsohime, Fahad, Cagdas, Deniz, Abraham, Roshini, Knutsen, Alan, Fevang, Borre, Bhattad, Sagar, Kiykim, Ayca, Erman, Baran, Arikoglu, Tugba, Unal, Ekrem, Kumar, Ashish, Geier, Christoph, Baumann, Ulrich, Neven, Bénédicte, Calas, Julie, Feuille, Elizabeth, Chan, Angela, Yesil, Gozde, Nammour, Justine, Bandet, Élise, Picard, Capucine, Benhsaien, Ibtihal, Lang, Peter, Atschekzei, Faranaz, Warnatz, Klaus, Hambleton, Sophie, Desai, Mukesh, Karakoc-Aydiner, Elif, Kolukisa, Burcu, Al-Muhsen, Saleh, Alosaimi, Mohammed, Cipe, Funda, Alazami, Anas, Hancioglu, Gonca, Can Meydan, Bilge, Sorte, Hanne, Stray-Pedersen, Asbjørg, Mammayil, Geetha, Tökmeci, Nazan, Shcherbina, Anna, Stepensky, Polina, Nasereddin, Adeeb, Rouzaud, Claire, Hoshino, Akihiro, Shamriz, Oded, Ledder, Oren, Maccari, Maria, Castro, Carla, Grimbacher, Bodo, Schmidt, Reinhold, Collin, Matthew, Zakharova, Victorya, Rohlfs, Meino, Walz, Christoph, Abel, Laurent, Malissen, Bernard, Marr, Nico, Klein, Christoph, Casanova, Jean-Laurent, Hauck, Fabian, Béziat, Vivien
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, 2022, 220, ⟨10.1084/jem.20220275⟩
Journal of Experimental Medicine, 2022, 220, ⟨10.1084/jem.20220275⟩
International audience; Patients with inherited CARMIL2 or CD28 deficiency have defective T cell CD28 signaling, but their immunological and clinical phenotypes remain largely unknown. We show that only one of three CARMIL2 isoforms is produced and f
Autor:
Jean-Leon Thomas, Helene Benveniste
Publikováno v:
Journal of Experimental Medicine. 220
Postmortem microstructural studies together with in vivo magnetic resonance imaging show that human arachnoid granulations are porous channels that serve as transient filtration conduits for cerebrospinal fluid to flow directly into dural interstitia
Autor:
Parchure, Anup, Tian, Meng, Stalder, Danièle, Boyer, Cierra K, Bearrows, Shelby C, Rohli, Kristen E, Zhang, Jianchao, Rivera-Molina, Felix, Ramazanov, Bulat R, Mahata, Sushil K, Wang, Yanzhuang, Stephens, Samuel B, Gershlick, David C, Von Blume, Julia
Funder: Yale-start up grant
Funder: NIGMS NIH HHS
Funder: Fraternal Order of Eagles Diabetes Research Center
Funder: Sir Henry Dale
Funder: University of Iowa
Funder: PI Daniel Eberl
Funder: Royal Society210481
Insu
Funder: NIGMS NIH HHS
Funder: Fraternal Order of Eagles Diabetes Research Center
Funder: Sir Henry Dale
Funder: University of Iowa
Funder: PI Daniel Eberl
Funder: Royal Society210481
Insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5032177e5f000dd6036ad38cd90a51
https://www.repository.cam.ac.uk/handle/1810/342696
https://www.repository.cam.ac.uk/handle/1810/342696