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Autor:
Femmy C. Stempels, Muwei Jiang, Harry M. Warner, Magda-Lena Moser, Maaike H. Janssens, Sjors Maassen, Iris H. Nelen, Rinse de Boer, William F. Jiemy, David Knight, Julian Selley, Ronan O’Cualain, Maksim V. Baranov, Thomas C.Q. Burgers, Roberto Sansevrino, Dragomir Milovanovic, Peter Heeringa, Matthew C. Jones, Rifka Vlijm, Martin ter Beest, Geert van den Bogaart
Publikováno v:
Journal of Cell Biology, 222
Journal of Cell Biology, 222, 7
The journal of cell biology 222(7), e202205130 (2023). doi:10.1083/jcb.202205130
Journal of Cell Biology, 222, 7
The journal of cell biology 222(7), e202205130 (2023). doi:10.1083/jcb.202205130
Contains fulltext : 292891.pdf (Publisher’s version ) (Open Access) Endosomal Sorting Complex Required for Transport (ESCRT) proteins can be transiently recruited to the plasma membrane for membrane repair and formation of extracellular vesicles. H
Autor:
Carla V. Rothlin, Sourav Ghosh
Publikováno v:
Journal of Cell Biology. 222
Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of mac
Autor:
Anna Klucnika, Peiqiang Mu, Jan Jezek, Matthew McCormack, Ying Di, Charles R. Bradshaw, Hansong Ma
Funder: Gurdon Institute Core Facility
Mechanisms that safeguard mitochondrial DNA (mtDNA) limit the accumulation of mutations linked to mitochondrial and age-related diseases. Yet, pathways that repair double-strand breaks (DSBs) in animal mito
Mechanisms that safeguard mitochondrial DNA (mtDNA) limit the accumulation of mutations linked to mitochondrial and age-related diseases. Yet, pathways that repair double-strand breaks (DSBs) in animal mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1de1cb52ef72575674f9c2b29b1d15
https://www.repository.cam.ac.uk/handle/1810/344209
https://www.repository.cam.ac.uk/handle/1810/344209
Autor:
Casey Beppler, John Eichorst, Kyle Marchuk, En Cai, Carlos A. Castellanos, Venkataraman Sriram, Kole T. Roybal, Matthew F. Krummel
Publikováno v:
The Journal of cell biology, vol 222, iss 3
T cells typically recognize their ligands using a defined cell biology—the scanning of their membrane microvilli (MV) to palpate their environment—while that same membrane scaffolds T cell receptors (TCRs) that can signal upon ligand binding. Chi
Autor:
Jean Paul Olivier, Maxwell Lewis Neal, John D. Aitchison, Alexis Kaushansky, Jasmin Coulombe-Huntington, Thierry Bertomeu, Carpp Ln, Mike Tyers, Fred D. Mast, Arti T. Navare
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
article-version (status) pre
article-version (number) 2
Viruses co-opt host proteins to carry out their lifecycle. Repurposed host proteins may thus become functionally compromised; a situation analogous to a loss-of-function mutation. We term such host proteins viral-induced hypomorphs. Cells bearing can
NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f381982707f598330b3f725a7b7a54b4
https://hdl.handle.net/10037/28316
https://hdl.handle.net/10037/28316
Autor:
Ann-Kathrin Weier, Mirka Homrich, Stephanie Ebbinghaus, Pavel Juda, Eliška Miková, Robert Hauschild, Lili Zhang, Thomas Quast, Elvira Mass, Andreas Schlitzer, Waldemar Kolanus, Sven Burgdorf, Oliver J. Gruß, Miroslav Hons, Stefan Wieser, Eva Kiermaier
Publikováno v:
Journal of Cell Biology. 221
Centrosomes play a crucial role during immune cell interactions and initiation of the immune response. In proliferating cells, centrosome numbers are tightly controlled and generally limited to one in G1 and two prior to mitosis. Defects in regulatin
Publikováno v:
Journal of Cell Biology. 221
Insulin levels are essential for the maintenance of glucose homeostasis, and deviations lead to pathoglycemia or diabetes. However, the metabolic mechanism controlling insulin quantity and quality is poorly understood. In pancreatic β cells, insulin
Autor:
Qinqin Jiang, Martina Foglizzo, Yaroslav I. Morozov, Xuejiao Yang, Arindam Datta, Lei Tian, Vaughn Thada, Weihua Li, Elton Zeqiraj, Roger A. Greenberg
Publikováno v:
Journal of Cell Biology. 221
The BRCA1-A complex contains matching lysine-63 ubiquitin (K63-Ub) binding and deubiquitylating activities. How these functionalities are coordinated to effectively respond to DNA damage remains unknown. We generated Brcc36 deubiquitylating enzyme (D
Autor:
Mike F. Renne, Robin A. Corey, Joana Veríssimo Ferreira, Phillip J. Stansfeld, Pedro Carvalho
Lipid droplets (LDs) are essential for cellular lipid homeostasis by storing diverse neutral lipids (NLs), such as triacylglycerol (TAG), steryl esters (SE), and retinyl esters (RE). A proper assembly of TAG-containing LDs at the ER requires Seipin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf315997dd4b408612826691275a98c5
http://wrap.warwick.ac.uk/168422/1/WRAP-Seipin-concentrates-distinct-neutral-lipids-interactions-acyl-chain-carboxyl-22.pdf
http://wrap.warwick.ac.uk/168422/1/WRAP-Seipin-concentrates-distinct-neutral-lipids-interactions-acyl-chain-carboxyl-22.pdf