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Autor:
Kevin M. Beussman, Charles E. Murry, Deok Ho Kim, Andrea Leonard, Hung Fat Tse, Jay Shendure, Alec S.T. Smith, William Stafford Noble, Nathan J. Sniadecki, Lil Pabon, Paul A. Fields, Alessandro Bertero
Publikováno v:
The Journal of Cell Biology
Mozzetta and Tedesco preview work from the Murry laboratory yielding insight into cardiac laminopathy pathogenesis mechanisms by analyzing chromatin compartment dynamics in a haploinsufficient model of the disease.
Lamins A and C are intermediat
Lamins A and C are intermediat
Autor:
Fei Yun Chen, Min Yu Huang, Yu Min Lin, Hsin Yi Chen, Ruey-Hwa Chen, Chi Huan Ho, Shu-Yu Lin, Mien Chie Hung
Publikováno v:
The Journal of Cell Biology
The BH3-only pro-apoptotic protein BIK is regulated by the ubiquitin–proteasome system. Chen et al. identify ASB11 as an E3 ligase for BIK ubiquitination and degradation and uncover different mechanisms that regulate ASB11 activity, and thus cell s
Autor:
Rakefet Ben-Yishay, Amit Shraga, Yuval Garini, Noga Kozer, Asaf Ashkenazy-Titelman, Yaron Shav-Tal, Avi Jacob, Pramod Kumar, Amir Mor, Avital Schwed-Gross, Noa Kinor
Publikováno v:
The Journal of Cell Biology
Ben-Yishay et al. measure the interactions of the mRNA export factor NXF1 with NPC components in individual nuclear pores in intact human cells and show that NXF1 functions on the cytoplasmic side of the NPC for the release of mRNA into the cytoplasm
Autor:
Daniel J. Marston, Philippe Roudot, Mitsu Ikura, Timothy A. Daugird, Christopher B. Marshall, Robert Rottapel, Jungsik Noh, María José Sandí, Sidney L. Lisanza, Klaus M. Hahn, John Sondek, Gaudenz Danuser, Mihai L. Azoitei
Publikováno v:
The Journal of Cell Biology
Azoitei, Noh, et al. engineer fluorescent biosensors to measure activation at the subcellular level and with subsecond kinetics of GEF-H1, a Rho GTPase that regulates cytoskeletal dynamics. In combination with computational image time series analysis
Autor:
Pedro E. Cruz, Christopher Janus, Karen A. Scott, Marshall S. Goodwin, Melanie R. Shapiro, Brenda D. Moore, Eric G. Krause, M. Zino Kuhn, Paramita Chakrabarty, Thomas B. Ladd, Andrew Judge, Yong Ran, Todd M. Brusko, Karen N. McFarland, Annette D. de Kloet, Cara L. Croft, Todd E. Golde, Benoit I. Giasson, Daniel Ryu, Yona Levites, Hunter S. Futch, Rachel L. Nosacka
Publikováno v:
The Journal of Experimental Medicine
A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of t
Autor:
Milena Pellikka, Norbert Perrimon, Frederik Wirtz-Peitz, Ulrich Tepass, Takashi Nishimura, Dong Yan, Jordan T. Silver, Yan Li, Tony J. C. Harris, Sérgio Simões, Richard Binari
Publikováno v:
The Journal of Cell Biology
Silver et al. show that the RhoGEF Cysts links apical polarity proteins to Rho1 and myosin activation at adherens junctions to support junctional and epithelial integrity in the Drosophila ectoderm.
The spatio-temporal regulation of small Rho GT
The spatio-temporal regulation of small Rho GT
Publikováno v:
Journal of Cell Biology. 220
Store-operated calcium entry (SOCE) through the Ca2+ release–activated Ca2+ (CRAC) channel is a central mechanism by which cells generate Ca2+ signals and mediate Ca2+-dependent gene expression. The molecular basis for CRAC channel regulation by th
Autor:
George Kannourakis, Susan N Christo, Sapna Devi, Stuart P. Berzins, Erica Wynne-Jones, Daniel G. Pellicci, William R. Heath, Thomas N. Burn, Raissa Fonseca, Simone L Park, Scott N. Mueller, Jerold Chun, Laura K. Mackay, Changwei Peng, Maximilien Evrard, Stephen C. Jameson, Yu Kato, Maleika Osman
Publikováno v:
The Journal of Experimental Medicine
S1PR5 impairs TRM cell differentiation by limiting T cell entry and promoting T cell egress from peripheral tissues. Local TGF-β signaling coordinates suppression of the T-bet–ZEB2–S1PR5 emigration axis, thus enforcing tissue residency.
Tis
Tis
Publikováno v:
Journal of General Physiology. 153
The ATP-binding cassette (ABC) transporter superfamily includes many proteins of clinical relevance, with genes expressed in all domains of life. Although most members use the energy of ATP binding and hydrolysis to accomplish the active import or ex
Autor:
Nicolas Rabas, Payam A. Gammage, Sarah Palmer, Louise Mitchell, Shehab Ismail, Stephen W.G. Tait, Joel S. Riley, Jim C. Norman, Iain R. Macpherson, Andrea Gohlke, Leandro Lemgruber Soares
Publikováno v:
The Journal of Cell Biology
Rabas et al. describe a novel means of intercellular communication in which processes evoked to mitigate cytotoxicity in metabolically stressed cells can promote PINK1-dependent packaging of mitochondrial DNA into exosomes to evoke invasive behavior