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Autor:
Bernd Kaina, Markus Lӧbrich, Christian Ebel, Teodora Nikolova, Lucie Iloff, Michael Ensminger
Publikováno v:
The Journal of Cell Biology
DNA double-strand breaks and chromosomal aberrations after treatment with N-alkylating agents likely arise as a result of replication fork collision with single-strand breaks generated during base excision repair.
Exposures that methylate DNA po
Exposures that methylate DNA po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f6bb357b9813b161350b354ef3dceb
The ADP-ribosylation factors (Arfs) are small GTPases regulating membrane traffic in the secretory pathway. They are closely related and appear to have overlapping functions, regulators, and effectors. The functional specificity of individual Arfs an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff347205cf8ca63e2d5971cc1414e205
Autor:
Rebeca San Martin, Priyojit Das, Renata Dos Reis Marques, Yang Xu, Justin M. Roberts, Jacob T. Sanders, Rosela Golloshi, Rachel Patton McCord
Publikováno v:
Journal of Cell Biology. 221
Prostate cancer aggressiveness and metastatic potential are influenced by gene expression and genomic aberrations, features that can be influenced by the 3D structure of chromosomes inside the nucleus. Using chromosome conformation capture (Hi-C), we
Autor:
Banafsheh Golchoubian, Andreas Brunner, Helena Bragulat-Teixidor, Annett Neuner, Busra A. Akarlar, Nurhan Ozlu, Anne-Lore Schlaitz
Publikováno v:
Journal of Cell Biology (JCB)
Nuclear pore complexes (NPCs) are channels within the nuclear envelope that mediate nucleocytoplasmic transport. NPCs form within the closed nuclear envelope during interphase or assemble concomitantly with nuclear envelope reformation in late stages
Autor:
Yuko Sato, Makio Tokunaga, Tetsuya Handa, Satoshi Uchino, Yasuyuki Ohkawa, Yuma Ito, Hiroshi Kimura
Publikováno v:
The Journal of Cell Biology
Uchino et al. have developed a genetically encoded probe to specifically detect the Ser2-phosphorylated, elongating form of RNA polymerase II in living cells. Ser2-phosphorylated RNA polymerase foci exhibit more dynamic motion than chromatin replicat
Autor:
Fubito Nakatsu, Hiroyuki Arai, Asami Kawasaki, Junya Hasegawa, Takehiko Sasaki, Hiroki Nakanishi, Michihiro Igarashi, Akiko Sakai, Junko Sasaki, Tomohiko Taguchi
Publikováno v:
Journal of Cell Biology. 221
Membrane contact sites (MCSs) serve as a zone for nonvesicular lipid transport by oxysterol-binding protein (OSBP)-related proteins (ORPs). ORPs mediate lipid countertransport, in which two distinct lipids are transported counterdirectionally. How su
Autor:
Samantha Bryce, Sarah B. Nyenhuis, Daniel Crosby, Jenny E. Hinshaw, Melissa R. Mikolaj, Tina H. Lee
Publikováno v:
Journal of Cell Biology. 221
ER network formation depends on membrane fusion by the atlastin (ATL) GTPase. In humans, three paralogs are differentially expressed with divergent N- and C-terminal extensions, but their respective roles remain unknown. This is partly because, unlik
Autor:
Jia-Ning Li, Yu-Cheng Zhang, Xuan-He Qin, Jin-Feng Yuan, Sen Li, Huai-Bin Hu, Li-Yun Liang, Qiu-Ying Han, Zeng-Qing Song, Kai Wang, Chun-Yu He, Pei-Yao Li, Xi-Ping Yu, Li Huiyan, Hai-Qing Tu, Xiao-Lin Shen, Xiao-Xiao Jian, Yu-Ling Xu, Guang-Ping Song, Ai-Ling Li, Min Wu, Na Wang, Tao Zhou
Publikováno v:
Journal of Cell Biology. 221
Primary cilia transduce diverse signals in embryonic development and adult tissues. Defective ciliogenesis results in a series of human disorders collectively known as ciliopathies. The CP110–CEP97 complex removal from the mother centriole is an ea
Autor:
Jaeho Yoon, Kunio Nagashima, Jian Sun, Ira O. Daar, Ziqiu Wang, Christopher J. Westlake, Hyun-Kyung Lee, Christina Carpenter, Yoo-Seok Hwang, Moonsup Lee
Publikováno v:
The Journal of Cell Biology
Lee et al. identify Dyrk1a as a new interaction partner that phosphorylates CEP97, which in turn promotes recruitment of Plk1. The complex of CEP97–Dyrk1a–Plk1 plays a substantive role in the maturation and location of centrioles/basal bodies and
Autor:
David M. Gilbert, Vishnu Dileep, Tetsuya Handa, Daniel A. Bartlett, Hiroshi Kimura, Steven Henikoff, Yasuyuki Ohkawa
Publikováno v:
Journal of Cell Biology. 220
Chromatin profiling in single cells has been extremely challenging and almost exclusively limited to histone proteins. In cases where single-cell methods have shown promise, many require highly specialized equipment or cell type–specific protocols