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Autor:
Alexis P. Pérez, Martí Aldea, Mònica B. Mendoza, Carme Gallego, Eva Parisi, Galal Yahya, David Moreno, Marta H. Artés
Publikováno v:
The Journal of Cell Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
© 2021 Yahya et al.
Stress granules (SGs) are conserved biomolecular condensates that originate in response to many stress conditions. These membraneless organelles contain nontranslating mRNAs and a diverse subproteome, but our knowledge of th
Stress granules (SGs) are conserved biomolecular condensates that originate in response to many stress conditions. These membraneless organelles contain nontranslating mRNAs and a diverse subproteome, but our knowledge of th
Publikováno v:
The Journal of Cell Biology
Ma et al. describe a closed feedback loop between DSBs and microtubules during c-NHEJ. DSBs result in increased microtubule dynamics through interphase centrosome maturation in G1 cells, which requires DNA-PK-AKT and 53BP1. Increased microtubule dyna
Autor:
Carolyn B. Coyne, Christina Megli
Publikováno v:
The Journal of Experimental Medicine
Hofbauer cells are primitive placental macrophages with a unique phenotype and role in fetal defense. Using transcriptomic and proteomic data, Thomas et al. analyze human first-trimester placental macrophages and delineate markers that identify them.
Autor:
Seiichiro Kurashige, Mitsunori Higa, Nozomi Sugimoto, Tomoki Matsumura, Masatoshi Fujita, Koki Narimatsu, Riko Ishimoto, Kouki Enokitani, Yota Tsuzuki, Kazumasa Yoshida
Publikováno v:
The Journal of Cell Biology
Ishimoto et al. show that the SLX4–XPF complex is an early key player in the DNA damage response evoked by a nucleoprotein obstacle that interferes with DNA replication, and the SLX4–ATR axis is critical for preventing chromosome instability upon
Publikováno v:
The Journal of Cell Biology
In the development of hyphal germ tubes of Candida albicans, a band of septin forms at the base of the germ tube (basal septin band). Later, a septin ring forms, which organizes the first septum within the germ tube (septin ring). We have investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d607fe0489683d4b2724c9d599d1f3cb
Autor:
Laurent Groc, Mar Petit-Pedrol
Publikováno v:
The Journal of Cell Biology
Petit-Pedrol and Groc review the regulatory role of NMDAR nanoscale organization and surface dynamics in glutamate synapse transmission and plasticity.
Understanding neurotransmitter system crosstalk in the brain is a major challenge in neurobio
Understanding neurotransmitter system crosstalk in the brain is a major challenge in neurobio
Autor:
Dan Simon, Melina Casadio
Publikováno v:
Journal of Cell Biology
The Journal of Cell Biology
The Journal of Cell Biology
The COVID-19 pandemic has created additional challenges for mid-career investigators seeking new academic opportunities. JCB asked scientists to share their experiences of uprooting their research careers and laboratories during the pandemic.
Autor:
Hongyuan Yang, Ximing Du
Publikováno v:
The Journal of Cell Biology
Du and Yang preview new work from the Fujimoto laboratory unveiling how seipin regulates the formation of nucleoplasmic lipid droplets.
Nuclear lipid droplets (nLDs) are poorly characterized outside of the liver. In this issue, Sołtysik et al.
Nuclear lipid droplets (nLDs) are poorly characterized outside of the liver. In this issue, Sołtysik et al.
Autor:
James J. Moresco, Stephen A. Adam, John R. Yates, Robert D. Goldman, Yixian Zheng, Joseph R. Tran, Danielle I. Paulson
Publikováno v:
The Journal of Cell Biology
The APEX2 proximity ligation method can identify RNA, protein, and DNA interacting with or in proximity to the nuclear lamina. This work suggests a potential regulation of mRNAs containing long 3′ UTRs and uncovers variation in lamina-associated ch
Autor:
Rajee Ganesan, Alex Marki, Johannes Roth, Gregory J. Golden, Konrad Buscher, Sara McArdle, David M. Smalley, Matthew Meyer, Jennifer M. Dan, Holger Winkels, Yi-Ting Yeh, Shu Chien, Zhichao Fan, Mitchell Kronenberg, Nadine Hartmann, William B. Kiosses, Victor Nizet, Jeffrey D. Esko, Ryosuke Saigusa, Klaus Ley, Jack D. Bui, Yoav Altman, Marco Orecchioni, Zbigniew Mikulski, Cristina B Lorenzini
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 218, iss 3
The Journal of experimental medicine, vol 218, iss 3
During bacterial sepsis, tethers break off from neutrophils rolling on the vessel wall, destabilizing neutrophil rolling and forming elongated neutrophil-derived structures (ENDS) in the blood circulation. ENDS are phosphatidylserine- and tetraspanin